COSMETIC CREAMS AND LOTIONS 111 was included on the basis that some studies have been made with evalua- tion of axillary odor from that area of a T shirt. Direct sniffing of the axilla has not yielded a level as high as overpowering but clothing such as a T shirt has. At this time, these 5 levels are suggested as covering the neces- sary range and also permitting evaluation on clothing if interested parties consider that this should be included in a test procedure. First consideration should be given to odor levels obtained by direct sniffing of the axilla. One laboratory found a correlation between direct sniffing of the axilla and that obtained from a 1-inch cotton ball swab of the axilla stored in a 1-oz. ointment jar with the cap liner removed from the cap of the jar. On repeating this work more than 5 years later, it was found that the odor on the swabs dissipated rapidly so they could not be used. The nature of the swab material varied from the original used and can account for the trouble. At the present time, Zobec pad material seems to retain axillary odors and correlate with direct sniffing of the axilla. What- ever is used must give comparable data with direct sniffing. 3-5. These paragraphs are self-explanatory. 6. Laboratories have found like odor intensities in L and R axilla when no deodorant preparation has been used. Therefor% the control axilla must have a definite characteristic axillary odor in order to judge the effectiveness of a product used in the treated axilla. For checking between laboratories, the bench mark preparation, mentioned under Antiperspirant Test is suggested. SUBCOMMITTEE ON DEODORANTS AND ANTIPERSPIRANTS G. W. Fredell, Chairman Dr. J. Longfellow Report on EVALUATION OF GOSMETIG GREAMS AND LOTIONS CREAMS ASD •,OTtOSS may be tested for safety, for efficacy or for attractiveness. Methods of testing for safety have not been discussed by this subcommittee, since they are very much the same for a wide variety of cosmetic products, and should be left for the consideration of the Com- mittee on Laboratory Methods for Product Testing as a whole. It may be worth while to remark in passing that an event greatly to be desired is the development of suitable in vitro tests to replace or supplement the lengthy and tedious animal tests now used to screen possible new ingredients. Advances in tissue culture techniques and the use of mast cells to assess

COSMETIC CREAMS AND LOTIONS 111 was included on the basis that some studies have been made with evalua- tion of axillary odor from that area of a T shirt. Direct sniffing of the axilla has not yielded a level as high as overpowering but clothing such as a T shirt has. At this time, these 5 levels are suggested as covering the neces- sary range and also permitting evaluation on clothing if interested parties consider that this should be included in a test procedure. First consideration should be given to odor levels obtained by direct sniffing of the axilla. One laboratory found a correlation between direct sniffing of the axilla and that obtained from a 1-inch cotton ball swab of the axilla stored in a 1-oz. ointment jar with the cap liner removed from the cap of the jar. On repeating this work more than 5 years later, it was found that the odor on the swabs dissipated rapidly so they could not be used. The nature of the swab material varied from the original used and can account for the trouble. At the present time, Zobec pad material seems to retain axillary odors and correlate with direct sniffing of the axilla. What- ever is used must give comparable data with direct sniffing. 3-5. These paragraphs are self-explanatory. 6. Laboratories have found like odor intensities in L and R axilla when no deodorant preparation has been used. Therefor% the control axilla must have a definite characteristic axillary odor in order to judge the effectiveness of a product used in the treated axilla. For checking between laboratories, the bench mark preparation, mentioned under Antiperspirant Test is suggested. SUBCOMMITTEE ON DEODORANTS AND ANTIPERSPIRANTS G. W. Fredell, Chairman Dr. J. Longfellow Report on EVALUATION OF GOSMETIG GREAMS AND LOTIONS CREAMS ASD •,OTtOSS may be tested for safety, for efficacy or for attractiveness. Methods of testing for safety have not been discussed by this subcommittee, since they are very much the same for a wide variety of cosmetic products, and should be left for the consideration of the Com- mittee on Laboratory Methods for Product Testing as a whole. It may be worth while to remark in passing that an event greatly to be desired is the development of suitable in vitro tests to replace or supplement the lengthy and tedious animal tests now used to screen possible new ingredients. Advances in tissue culture techniques and the use of mast cells to assess