POLYGLYCEROL ESTERS IN PHARMACEUTICAL PREPARATIONS 483 self-emulsifying waxes. Thus, the addition of hexaglycerol mono61eate to mineral oil produces a clear oil which is readily rinsed off the hands with water. Other esters, such as decaglycerol tetraoleate, can be used in a similar fashion with vegetable oil. The fact that the polyglycerol esters are edible opens up many possible applications in the pharmaceutical field. Thus, their use as emulsifiers in edible emulsions containing vegetable oils and as solubilizers for vitamins is currently under investigation. SUMMARY The chemical and physical characteristics of a series of polyglycerol esters are presented. The utility of this versatile group of compounds is illus- trated. The stability of O/W and W/O emulsions prepared with the aid of these esters is examined. Formulations of practical cosmetics con- taining polyglycerol esters are given. Preliminary tests suggest that these emulsifiers do not interfere with the activity of Hexachlorophene. (Received January 15, 1964) REFERENCES (1) W. C. Griffin in E. Sagatin, Cosmetics: Science and Technology, Interscience Publishers, Inc., New York, 1004-05 (1955). (2) W. F. Rehm, Milchwissenschaft, 16, 310 (1961). (3) A. Bille and A. Mirimanoff, y. Pharm. Pharmacol., 2, 685 (1950). (4) M. G. deNavarre and H. E),Bailey, y.•Soc. Cosmetic Chemists, 7, 427 (1956). (5) M. G. deNavarre, Ibid., 8, 68 (1957). (6) L. F. Tice and M. Bart, Ibid., 9, 171 (1958). (7) D. L. Wedderburn, Ibid., 9, 210 (1958). (8) R.G. Harry, Modern Cosmeticology, Leonard Hill (Books) Ltd., London, 1962, p. 566. (9) N.H. Nash and V. K. Babayan, Baker's Digest, 37, 72 (1963). (10) Patent Pending Serial No. 14477. (11) K. S. Markley, Fatty .4cids, Part 2, Interscience Publishers, Inc., New York, 1961, pp. 826-27. (12) H. Kaunits, C. A. Slanetz and V. K. Babayan, y..4m. 01l Chemists' Soc., 41, 434 (1964). (13) Federal Register, July 2, 1963, p. 6783 March 19, 1963, pp. 2675-76. (14) W. C. Griffin, y. Soc. Cosmetic Chemists, 1, 311 (1949). (15) W. C. Griffin in E. Sagatin, Cosmetics: Science and Technology, Interscience Publishers, • Inc., New York, 1955,.pp. 1018-20. (16) [dem., Ibid., p. 1029.

484 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS IVth. INTERNATIONAL CONGRESS ON SURFACE ACTIVE SUBSTANCES under the Presidency of Honour of H. R. H. Prince Albert of Belgium The Organizing Committee of the Comitd International de la Ddtergence invites you to take part in the IVth. INTERNATIONAL CONGRESS ON SURFACE ACTIVE SUBSTANCES which will take place in the "Universit• Libre de Bruxelles" (58, Avenue Franklin Roosevelt, Bruxelles 5) ,from 7th.-l•lh. September 196& ( ENERAL SECRETARIAT OF THE CON( RESS 49, Square Marie-Louise, Bruxelles 4 Tel. 35.40.80- Telegr. FECHIMIE, BRUXELLES