TOPICAL PREPARATIONS AND THE HEALING OF SKIN WOUNDS 517 6OO 500 400 300 20C I00 3 6 9 12 15 18 DAYS AFTER WOUND INFLICTED Figure 5.--Tensile strength of wounds treated with corticosteroid or with pantothenylol. 600 m 500 z 400 ,,, 300 z •- •00 I00 3 6 9 I: • 15 I$ DAYS AFTER WOUND INFLICTED Figure &--Tensile strength of untreated wounds (composite of controls).

518 JOURNAl. O1: THE SOCIETY O!,' COSMETIC CHEMISTS SUMMARY I. Under controlled conditions, with the mouse as the experimental animal, it has been shown that the tensile strength of a standardized skin wound increased as the wound healed. II. The effects of several preparations applied topically to the standard wound were demonstrated by tensile strength measurements. (Received Aplil 1, 1964) REFERENCES (1) O. W. Neuhaus, H. F. Balegno, and A.M. Chandler, Proc. Soc. Exptl. Biol. Med., 107, 960 (1961). (2) J. A. Schilling, W. Joel, and H. M. Shurley, Surgery, 46, 702 (1959). (3) B. N. White, M. R. Shetlar, and J. A. Schilling,/Inn. N.Y./Icad. Sci., 94, Art 1 297 (1961). (4) M. R. Shetlar, E.G. Lacefield, B. N. White• and J. A. Schilling, Proc. Soc. Expll. Biol. Med., 100, 501 (1959). (5) M. Ahmad./Inn. Biochem. Exptl. Med. (Calcutta), 21, 295 (1961). (6) H. J. Fromm and R. C. Nordlie, Biochim et Biophys./Icta, 31,357 (1959). (7) M. B. Williamson and W. Guschlbauer, Nature, 192, 454 (1961). (8) P. Weiss, Harvey Lectures Ser., 55, 13 (1959-60). (9) E. E. Peacock, Jr.,/Inn. Surg., 155, 251 (1962). (10) C. Ragan, E. L. Howes, C. M. Plotz, E. M. Meyer, and J. W. Blunt, oeroc. Soc. Exptl. Biol. Med., 72, 718 (1949). (11) S.H. Boulas, y. Invest. Dermatol., 32, 75 (1959). (12) C.-M. Fajers and B. Zederfeldt,/icta Pathol., 47, 225 (1959). (13) A. Innocenz, Ormonologia, 17, 129 (1957). (14) A. I. Bukhonova, Doklady/Ikad. Nauk. S.S.S.R., 124, 477 (1959). (15) A. I. Bukhonova, Ibid., 134, 1256 (1960). (16) A. A. Voitkevich, and A. I. Bukhonova, Problemy Endokrinol i Gormonoterap., 7, 59 (1961). (17) E. Moltke, Endocrinology, 63, 931 (1958). (18) B. S. Karsavina and L. I. Muzykant, Doklady/Ikad. Nauk. S.S.S.R., 123, 189 (1958). (19) L. Fiore-Donati and E. Moltke,/Icta Endocrinol., 34, 430 (1960). (20) P. Boiteau and A. R. Ratsimamanga, Bull. Soc. Sci. Bretagne, 32, 28 (1957). (21) P. Bolteau and A. R. Ratsimamanga, Ibid., 34, (Extra No.) 307 (1959). (22) G. Farris, Minerva Med., 56, 2244 (1960). (23) B. Rovatti and R. J. Brennan, Ind. Med. and Surg., 28, 364 (1959). (24) Anon., y./Im. Med./Issoc., 110, 813 (1938). (25) H. J. Heite and S. E. Muller-Niewerth,/Irzneimittel-Forsch., 8, 595 (1958). (26) T. Juszkiewicz and C. Zorawski, Med. IKeterynar (Poland), 14, 346 (1958). (27) R. Mouchette,/irch. Biol. (Liege), 68, 513 (1957). (28) S. H. Rubin, y. Soc. Cosmetic Chemists, 11, 160 (1960). (29) S. B. Curri, Boll. Soc. Ital. Biol. Sper., 35, 1762 (1959). (30) B.S. Karsavina, M. Z. Alferera, L. A. Glembodskaya, V. M. Liftsman, G. D. Zenkevich, and G. A. Gzehlyak, U.S.S.R., Pat. No. 130,159, July 15, 1960. (31) E. E. Peacock, Jr., Proc. Soc. Exptl. Biol., 105, 380 (1960). (32) Ph. Sandblom, P. Petersen, and A. Muren,/icta Chir. Scand., 105, 252 (1953). (33) J. F. Prudden, G. Nishihara, and L. Baker, Surg. Gynecol. Obstet., 105, 283 (1957). (34) J. F. Prudden, Transplant. Bull., 5, 14 (1958). (35) R. E. Paulette and J. F. Prudden, Surg. Gynecol. Obstet., 108, 406 (1958). (36) G. Nishihara and J. F. Prudden, Ibid., 107, 305 (1958). (37) J. F. Prudden, G. Nishihara, and L. Ocampa, Ibid., 107, 481 (1958). (38) M. S. Schwartz, F. Gump, and J. F. Prudden• Surg. Forum, 10, 308 (1960). (39) J. F. Prudden, T. Inoue, and L. Ocampa,/irch. Surg., 85, 245 (1962). (40) E. Wolarsky and J. F. Prudden, Ibid., 85, 404 (1962). (41) J. F. Prudden, O. Gabriel, and B. Allen, Ibid., 86, 157 (1963). (42) J Charhey, M. B. Williamson, and F. W. Bernhard, Science, 105, 396 (1947).