88 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS ment from the other moisturizer (Tables V and VI). These improvements moderated over time in a consistent manner. The pattern of change over the 10 hr is most clearly evident in Figs. 2 and 3 in the results for the two more effective moisturizers. This led us, as a follow-up to our study, to investigate the pattern of the onset of action, with examination of the facial areas found to respond best (around the eyes and on the cheeks). Baseline SFL scores were quantified in accordance with the method described previously in ten subjects, who then applied water to one half-face and the most active moisturizer (O) to the other half-face. Two judges than independently evaluated the results every half-hour for 2 hr. Figure 4 shows that for the active treatment, reduc- tions in SFL's began to be apparent at 1 V2 hr. They did not attain statistical significance against baseline until 2 hr (P 0.01 around the eyes, P 0.05 on the cheeks). The re- ductions at 2 hr were not as extensive as those recorded in the main part of our study at 3 hr, thus indicating that maximum effect occurs around 2 to 3 hr after each applica- tion. Onset of action was slower than had been anticipated which suggests that significant re- duction in SFL's by an effective moisturizer may require sufficient time for significant penetration. This study, with detailed quantitative appraisal by two trained judges, yielded a rank order of treatments (O, ML, MF, water, L, no treatment) that provided an independent reference standard against which to compare the ranking (O, ML, MF, L, water, no treatment) from our subsequent study (8), in which a panel of untrained consumers qualitatively evaluated the overall effect of these same moisturizers in a separate group of subjects. The results deriving from these two different methods showed certain major simi- larities, confirming that an untrained consumer panel could perceive qualitatively the same differences in moisturizer activity that the two trained judges ascertained quanti- tatively. Both methods detected and confirmed similar differences among most of the comparison treatments. Namely, both studies: 1. found O and ML to be the more effective moisturizers. The two judges determined O to be significantly more effective than ML, whereas the panel ascertained a trend toward O being more effective 2. found MF and L to be less effective moisturizers 3. found that water and L differed by only a few points, and thus the two studies varied in their ranking of these two treatments 4. ranked all moisturizers and water more highly than no treatment. The method and detailed results of the controlled panel study are described in the following article. REFERENCES (1) H.J. Eiermann, Cosmetic ingredient labeling, Drug & Cosmet. Ind., 118, 42-45 (1976). (2) D. A. Davis, Cosmetic regulation. The honeymoon is over! Drug & Cosmet. Ind., 117, 38-41, 96-100 (1975). (3) I. M. Gibson, The evaluation of hand-care preparations, J. Soc. Cosmet. Chem., 24, 31-41 (1973). (4) E. R. Jolly and C. A. Sloughfy, Clinical evaluation of baby oil as a derreal moisturizer, J. Soc. Cosmet. Chem., 26, 277-34 (1975).

TOPICAL MOISTURIZERS 89 (5) D. H. Powers and C. Fox, The effect of cosmetic emulsions on the stratum corneum, J. Soc. Cosmet. Chem., 10, 109-16 (1959). (6) J. K. Prall, Instrumental evaluation of the effects of cosmetic products on skin surfaces with particular reference to smoothness, J. Soc. Cosmet. Chem., 24,693-707 (1973). (7) M. S. Christensen, C. W. Hargens, S. Nacht, and E. H. Gans, Viscoelastic properties of intact human skin: instrumentation, hydration effects and the contribution of the stratum corneum, J. Invest. Derre., 69, 282-6 (1977). (8) E. W. Packman and E. H. Gans, The panel study as a scientifically controlled investigation: moisturizers and superficial facial lines,J. Soc. Cosmet. Chem., 29, 91 (1978).