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j. Soc. Cosmet. Chem., 44, 13-21 (January/February 1993) A comparison of antiperspirant data analysis methods FRANK H. DIETRICH II, JAMES P. BOWMAN, BARBARA M. FATH, and JOHN E. WILD, Hill Top Research, Inc., Cincinnati, OH 45147 (F.H.D., J.P.B., B.M.F., J.E.W.), and Northern Kentucky University, Highland Heights, KY 41076 (F.H.D.). Received January 22, 1992. Synopsis The purpose of an antiperspirant study may be to estimate the efficacy of a product, to compare two or more products, or to provide support for an advertising claim. In any of these cases, various statistical methods are available to analyze the data. In this paper, we will compare three methods of estimating the efficacy of a single antiperspirant product. Over the years Hill Top Research, Inc. has collected vast amounts of antiperspirant data, and this large base of historical information will be utilized for comparing the statistical methods of interest. This investigation suggests that one of the methods is preferable to the others. INTRODUCTION Evaluation of human perspiration evolved from simply viewing the amount of sweat produced during a set time period to collecting and weighing the actual sweat in the axillae. Collecting and weighing axillary perspiration through the use of absorbent pads has been used since the early 1950s and with minor modifications has remained fairly consistent for over 40 years. Analyses have also evolved over time. The analysis of the early visual data estimated reduction in the amount of perspiration seen. One form of analysis of the data collected with absorbent pads is done using treated axilla over untreated axilla ratios, adiusting the posttreatment ratios by a pretreatment ratio (1). As early as 1964 the use of analysis of variance to test for differences between treatments was employed (2). Adaptation of the analysis of variance (i.e., analysis of covariance, etc.) and other methods have also been used to analyze antiperspirant data. In this paper, we will consider experiments with the obiective of estimating the percent reduction obtained following use of an antiperspirant test product. That is, we will consider experiments designed to estimate the average percent reduction in perspiration that could be achieved by consumers using an antiperspirant. ANTIPERSPIRANT TERMINOLOGY Terminology that is typically used to define the various stages of an antiperspirant study is as follows: 13