Study Parameters measured Method Measurement method Skin area studied Time, w C. asiatica product Placebo/ comparatorp AEs/dropouts Tongsrikeaw (21) Wrinkle Digital camera Rao-goldman 15 mm lateral from lateral canthus 0 3.48 ± 0.55 3.48 ± 0.55 ns 0 4 3.48 ± 0.55 3.48 ± 0.55 ns Five-point visual score 8 3.42 ± 0.55 3.44 ± 0.54 0.7 12 3.38 ± 0.53 3.42 ± 0.54 0.5 Measured at w 12 15 mm below lower eyelid 0 3.36 ± 0.55 3.36 ± 0.55 NS 4 3.36 ± 0.55 3.36 ± 0.55 NS 8 3.32 ± 0.55 3.34 ± 0.54 0.6 12 3.30 ± 0.54 3.32 ± 0.54 0.6 Visioscan VC98 Skin wrinkles 15 mm lateral from lateral canthus 0 58.6 ± 6.6 58.3 ± 6.0 0.6 4 56.8 ± 5.9 56.6 ± 5.9 0.7 8 54.1 ± 5.9 53.9 ± 5.9 0.7 12 51.9 ± 5.9 51.4 ± 6.2 0.5 15 mm below lower eyelid 0 56.2 ± 7.1 54.9 ± 6.9 0.1 4 54.1.±6.9 53.3 ± 6.7 0.2 8 50.2 ± 6.2 49.7 ± 6.7 0.002 12 47.1 ± 5.6 46.6 ± 6.6 0.5 Satisfaction Patient satisfaction questionnaire Patient satisfaction score 15 mm from lateral canthus. 15 mm below lower eyelid 12 3.52 ± 1.05 3.36 ± 0.99 NA AEs Visual observation Either site 4 No AE No AE 8 No AE No AE 12 No AE No AE Table III Continued EFFICACY AND SAFETY OF CENTELLA ASIATICA 447

Study Parameters measured Method Measurement method Skin area studied Time, w C. asiatica product Placebo/ comparatorp AEs/dropouts Zhang et al. (22) Periorbital wrinkles Photos assessed by nine dermatologists 10-point scale Crow’s feet 0 3.4 ± 1.5 3.3 ± 1.4 4 3.0 ± 1.5 3.3 ± 1.4 0.02 8 2.6 ± 1.2 3.2 ± 1.3 0.001 One dropout work- related cause 12 2.5 ± 1.2 3.3 ± 1.4 0.001 AEs, NR Visioscan VC98 SEw-value Crow’s feet 12 Increased decreased 0.05 Self-assess-ment Coarse and fi ne wrinkles Crow’s feet 12 Only fi ne wrinkles improved 0.05 * p compare intervention with placebo/comparator . **Lee et al., not clear what these numbers mean (see comments in the article). Table III Continued JOURNAL OF COSMETIC SCIENCE 448