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J. Cosmet. Sci., 72, 1–16 (January/February 2021) 1 Formulation and In Vitro and In Vivo Assessment of Natural Emulgel Containing Lemongrass Essential Oil ABDEL NASER ZAID, NIDAL JARADAT, RAMZI SHAWAHNA, FATEMA HUSEEN, AHMAD M. EID, ALAA ATTOUN, ABEER SANDOUKA, TALAL ABED ALHADI, THARAA HILAL, and WISSAL AQTASH , Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus 0000, Palestine (A.N.Z., N.J., F.H., A.M. E., A.A., A.S., T.A.A., T.H., W.A.), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus 0000, Palestine (R.S.) Accepted for publication August 18, 2020. Synopsis This study aimed to develop a topical emulgel formulation from olive oil and lemongrass (LG) extracts and to evaluate its in vitro and in vivo (sensorial) properties in addition to its sun protection factor (SPF) value. The primary emulsion and the gel were prepared separately, and then they were levigated together to formulate the emulgel. The produced emulgel was evaluated for its physical appearance, pH, spreadability, and stability. The SPF value of emulgel was evaluated by applying the Mansur equation. Moreover, an in vivo sensorial assessment was conducted on the emulgel through a crossover study by including 20 volunteers. The results confi rm good stability for emulgel formulations because there was no signifi cant change in the pH value, no micelle inversion, or phase separation detected. The emulgel recorded a moderate SPF value (5.5) which can be useful for daily use, especially in tanned skin subjects. Moreover, the sensorial assessment of LG and blank emulgels showed a signifi cant change in the cooling effect, odor, and smoothness and add some kind of moisture. In fact, there was a signifi cant difference in overall properties between the two formulations where the p-value was less than 0.05. It is concluded the emulgel formulation containing LG and olive oil could be benefi cial in terms of applicability and stability and can be easily formulated in pharmaceutical facilities. Besides, it would be useful for daily use because of the overall suitable properties, especially odor, feel, and SPF value. INTRODUCTION Humans generally tend to use cosmetic preparations to improve their general look and skin appearance (1). Creams and gels are the most used cosmetic formulations because they have suitable characteristics that are not usually available in other semisolid prepara- tions. These characteristics include low greasiness, suitable viscosity, skin feeling, and smoothness (2). Another important semisolid preparation which contains both gel and cream properties is emulgel. This formulation includes the incorporation of emulsion in Address all correspondence to Abdel Naser Zaid at anzaid@najah.edu.