JOURNAL OF COSMETIC SCIENCE 80 ( 51) G. Saintigny, F. X. Bernard, F. Juchaux, N. Pedretti, and C. Mahé, Reduced expression of the adhesion protein tensin1 in cultured human dermal fi broblasts affects collagen gel contraction, Exp. Dermatol., 17, 788–789 (2008). ( 5 2) S. Terawaki, V. Camosseto, F. Prete, T. Wenger, A. Papadopoulos, C. Rondeau, A. Combes, C.R. Rodrigues, T.P.V. Manh, M. Fallet, L. English, R. Santamaria, A.R. Soares, T. Weil, H. Hammad, M. Desjardins, J.P. Gorvel, M.A.S. Santos, E. Gatti, P. Pierre. RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J Cell Biol 210 1133–1152 (2015). ( 5 3) E. Boelsma, H. F. J. Hendriks, and L. Roza, Nutritional skin care: health effects of micronutrients and fatty acids, Am. J. Clin. Nutr., 73, 853–864 (2001). ( 5 4) D. Groen, D. S. Poole, G. S. Gooris, and J. A. Bouwstra. Investigating the barrier function of skin lipid models with varying compositions, Eur. J. Pharm. Biopharm., 79, 334–342 (2011). ( 5 5) G. Peterson, S. Rapaka, N. Koski, M. Kearney, K. Ortblad, L. Tadlock. A robust sebum, oil, and particu- late pollution model for assessing cleansing effi cacy of human skin. Int J Cosmet Sci 39 351–354 (2017). ( 5 6) A. Ferreira and M. Rapoport, The synapsins: beyond the regulation of neurotransmitter release, Cell. Mol. Life Sci., 59, 589–595 (2002). ( 5 7) T.G. Richardson, E. Sanderson, T.M. Palmerid, M.A. Korpelaid, B.A. Ference, G.D. Smith, M. V. Holmes. Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. PLoS Med 17 1–22 (2020). ( 5 8) P.J. Talmud, F. Drenos, S. Shah, T. Shah, J. Palmen, C. Verzilli, T.R. Gaunt, J. Pallas, R. Lovering, K. Li, J.P. Casas, R. Sofat, M. Kumari, S. Rodriguez, T. Johnson, S.J. Newhouse, A. Dominiczak, N.J. Samani, M. Caulfi eld, P. Sever, A. Stanton, D.C. Shields, S. Padmanabhan, O. Melander, C. Hastie, C. Delles, S. Ebrahim, M.G. Marmot, G.D. Smith, D.A. Lawlor, P.B. Munroe, I.N. Day, M. Kivimaki, J. Whittaker, S.E. Humphries, A.D. Hingorani. Gene-centric Association Signals for Lipids and Apolipo- proteins Identifi ed via the HumanCVD BeadChip. Am J Hum Genet 85 628–642 (2009). ( 5 9) A. Szász, G. Strifl er, A. Vörös, B. Váczi, V. Tubak, L.G. Puskás, N. Belso, L. Kemény, I. Nagy. The ex- pression of TAM receptors and their ligand Gas6 is downregulated in psoriasis. J Dermatol Sci 71 215– 216 (2013). (6 0 ) H. Gevensleben, U.-J. Göhring, R. Büttner, L.C. Heukamp, G. Kunz, T. Dimpfl , C. Jackisch, O. Ortmann, U.-S. Albert, R. Bender, F. De Snoo, O. Krijgsman, A.M. Glas, Y.H. Ergönenc, C. Vogel, A. Dykgers, C. Langwieder, M. Rees, T. Anzeneder. Interleukin-15 increases calcineurin expression in 3T3-L1 cells: Possible involvement on in vivo adipocyte differentiation. Int J Mol Med 26 837–843 (2010). (6 1 ) A.J. Piper, J.L. Clark, J. Mercado-Matos, A.N. Matthew-Onabanjo, C.-C. Hsieh, A. Akalin, L.M. Shaw. Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non- small cell lung cancer (NSCLC). PLoS One 14 e0220567 (2019). (6 2 ) N. Spravchikov, G. Sizyakov, M. Gartsbein, D. Accili, T. Tennenbaum, E. Wertheimer. Glucose Effects on Skin Keratinocytes. Diabetes 50 1627 LP – 1635 (2001).

J. Cosmet. Sci., 72, 81–89 (January/February 2021) 81 Luxury Cues of Cream Heighten the Reward Value of Its Tactile Experience NAOYASU HIRAO, MADOKA NORIUCHI, HIROKO ISOBE, and YOSHIAKI KIKUCHI , Shiseido Global Innovation Center , Yokohama-shi 220-0011, Japan (N.H., H.I.), Division of Human Health Sciences, Graduate School of Tokyo Metropolitan University , Tokyo 116-8511, Japan (M.N., Y.K.) Accepted for publication October 25, 2020. Synopsis In our previous study, the brain activity of areas related to social dominance [dorsomedial prefrontal cortex (DMPFC)] and reward [ventral striatum (VS)] was compared before and after providing information (cue) indicating that an applied cream was luxury. Both the DMPFC and VS showed signifi cantly higher activation after this cue, and the cue also facilitated the connection between the DMPFC and VS via the dorsolateral prefrontal cortex (DLPFC). Therefore, it may likewise have an effect on primary (SI) and secondary (SII) somatosensory areas. In the current study, we explored this hypothesis by performing correlation analyses of the same data and found a signifi cant positive correlation between the VS and the right SII during the application of the cream even before the cue, and signifi cant correlations between the VS and the right SI, SII, and DLPFC after. These results suggest that the emotional value based on texture is mainly processed through the connection between the SII and VS, and luxury cues further facilitate the connection between the VS and the SI, which plays a role in discriminating the physical aspects of creams. Therefore, we provide neuroscientifi c evidence of the synergistic effect of luxury cues on pleasant tactile and social dominance feelings. INTRODUCTION The primary functional value of skincare products is in the maintenance of skin condi- tion. Furthermore, product information that indicates priorities such as luxury can have an emotional and cognitive value and is thus an important factor to consider when devel- oping valuable cosmetics for consumers. In our previous study (1), the ventral striatum (VS), which is involved in reward processing, and the dorsomedial prefrontal cortex (DMPFC), which is related to social dominance, showed higher activity during the ap- plication of a luxury cream than a basic cream after providing visual information indicat- ing that it was luxury (cue), whereas no regions showed signifi cant activity before providing the cue. Moreover, activity in the right dorsolateral prefrontal cortex (DLPFC) was positively correlated with activity in both the DMPFC and VS after providing the Address all correspondence to Naoyasu Hirao, naoyasu.hirao@shiseido.com