112 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS (6) A number oflipids, hydrocarbons and silicone, when used as vehicles produced similar rates of absorption whereas polyethylene glycol vehicles produced low rates of absorption of methyl salicylate. (7) When esters and salts of salicylic acid were tested involatile solvents, methyl salicylate was more rapidly absorbed than all others. Salicylic acid, salicyl phosphate and several salts gave significantly lower plasma levels than other esters. (8) Methyl nicotinate had no effect upon percutaneous absorption when added to mineral oil or polyethylene glycol vehicles. ACKNOWLEDGMENTS Atcknowledgments: The authors gratefully acknowledge the technical assistance provided by Mrs. Clementina Ercoli, the extensive statistical analyses performed by Messrs. William Frey, John Grano and Lyn Steen and the many services provided by Dr. Armin Wilson's Department of Organic Chemistry at Bristol-Myers. REFERENCES (1) Gross, M., and L. A. Greenberg, "The Fate of Salicylate in the Body: Absorption from the Skin," In The Salicylates, New Haven, Hillhouse House (1958), pp. 24-28. (2) Valette, Guillaume, and Cavier, Raymond, y. physioL (Paris), 39, 137 (1947). (3) Rothman, S., "Physiology and Biochemistry of the Skin," Chicago, University of Chicago Press (1954), pp. 26-59. (4) Schachter, D., and J. G. Manis, •t. C/in. Invest., :t7, 800 (1958). (5) Brodie, Bernard B., Udenfriend, Sidney, and Coburn, Alvin F., y. Pharm. Exptl. Therap., 80, 114 (1944). (6) Moore, P. G., Biometrika, 44, 482 (1957). (7) Tuckey, John W., Technometrics, Feb., 31 (1959). (8) Student's test. (9) Analysis of Variance. (10) Stolar, Moese E., Rossi, G. Victor, and Barr, Martin, "The Effect of Various Ointment Bases on the Percutaneous Absorption of Sallcylates II. Effect of Surface Active Agents," •. /lm. Pharm. /lssoc., $ci. Ed., in press. (11) Stolar, Moese E., Rossi, G. Victor, and Bart, Martin, "The Effect of ¾arious Ointment Bases on the Percutaneous Absorption of Salicylates I. Effect of Type Ointment Base," Ibid., in press. (12) Shelly, Walter B., and Melton, Frank M., y. Invest. Dermatol., la, 61 (1949). (13) Lang, Edwin P., Vos, Elizabeth A., Kunze, Frieda M., and Urnberger, Ernest J., y. Phar- raaco/. Exptl. Therap., 87, 52 (1947). (14) Strakosch, E. A., and Clark, W. G.,/lm. •. Pied. Sci., 205, 518 (1943). (15) Halpern, B. N., Gaudin, O., and Stiffel, C., Cornpt. rend. soc. bioL, 142, 819 (1948). (16) Higuchi, T., y. Soc. Cosmetic Chemists, 11, 85 (1960). (17) Malkinson, Frederick D., .7. Soc. Cosmetic Chemists, to be published.

SOCIETY OF COSMETIC CHEMISTS OF GREAT BRITAIN Syllabus 1959-1960 Qfficer s President: R. H. Marriott, D.Sc., F.R.I.C. Vice-President: H. W. Hibbott, M.Sc., Ph.D., A.R.I.C. Hon. Secretary: L. S. Smith Hon. Treasurer: R. E. Spate Hon. Editor: A. Herzka, B.Sc., A.R.I..C. Hon. Education Officer: K. G. Johnson, B.Sc., Ph.D., A.R.I.C. Hon. Publicity Officer: G. A. C. Pitt, M.Sc., F.R.I.C. Members of the Council S. J. Bush, F.R.I.C. R. T. Dobson K. G. Johnson, B.Sc., Ph.D., A.R.I.C. A. W. Middleton, B.Sc., Ph.D., F.R.I.C. L. P. Torry, B.Sc. (Miss) J. B. Wilkinson, B.A., B.Sc., F.R.I.C. General Secretary Mrs. E. Millman, B.A., B.Sc. Scientific meetings take place at the Royal Society of Arts, John Adam Street, I,ondon, W.C. 2. The first meeting of the year was held on January 18th. Mr. A. B. Killnet spoke on "The Use of Polyoxyethylene Deriva- tives in Cosmetics." On February 12th Mr. M. H. Quenouille of the Lon- don School of Economics and Political Science gave a paper on "The Design of Experiments." 113