SKIN FRICTION 65 (4) J. K. Prall, Instrumental evaluation of the effects of cosmetic products on skin surfaces with particular reference to smoothness,J. Soc. Cosmet. Chem., 24, 693-707, 1973. (5) P. F. D. Naylor, The skin surface and friction, Br.J. Dermatol., 67, 239-248, 1955. (6) A. F. E1-Shimi, In vivo skin friction measurements,J. Soc. Cosmet. Chem., 28, 37-51, 1977. (7) D. R. Highley, M. Coomey, M. DenBeste and L.J. Wolfram, Frictional properties of skin, J. Invest. Dermatol., 69, 303-305, 1977.

J. $oc. Cosmet. Chem., 32, 67-73 (March/April 1981) The mechanism of antiperspirant action by aluminum salts. I. The effect of cellophane tape stripping on aluminum salt-inhibited eccrine sweat glands RICHARD P. QUATRALE, PH.D., ARLENE H. WALDMAN, JANICE G. ROGERS, and CARL B. FELGER, PH.D., Gillette Research Institute, I413 Research Blvd., Rockville, MD 20850. Received September 19, 1980. Synopsis Studies were performed to determine the relative site of inhibition in the sweat gland caused by the three antiperspirants, aluminum chlorohydrate (ACH), aluminum zirconium chlorohydrate glycine complex (AZAP) and aluminum chloride (A1C13). For these studies, human forearm sweat glands were examined using the Scotch tape stripping procedure, a technique which removes the stratum corneum layer of skin and exposes the stratum granulosum layer of the viable epidermis. As judged by the degree to which sweat glands inhibited by overnight occlusive application of these antiperspirants could be restored to firing after Scotch tape stripping, ACH and AZAP acted most superficially, whereas A1C13 functioned at a level below the stratum corneum. INTRODUCTION To understand the mechanism of action by which aluminum-based antiperspirant salts inhibit eccrine sweat gland function, it is useful to know the site within the gland at which those salts function. Several regions of the gland which are potential targets for inhibition by these salts can be delineated. First, there is the neuroglandular junction. If it is impeded from releasing acetylcholine, for example by the use of an anticholinergic such as scopolamine, then sweat gland secretion itself does not occur (1). A second challenge point is the secretory coil in the derreal layer of skin. If an agent can affect or inhibit the active transport processes which are intricately involved in the secretion of salt and water, then no sweat will appear at the skin surface (2,3). The third potential site of activity is the resorptive duct portion of the gland, also in the dermis. Disruption of the integrity of this area of the sweat gland, for example, might cause extensive reabsorption of secreted sweat back into the interstitial space [the "leaky hose" hypothesis as proposed by Papa and Kligman (4)]. Finally, an aluminum salt might function by blocking the flow of sweat to the skin surface through the 67