70 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS : Before Treatment After Treatment, Before Stripping Figure 1. The effect of cellophane tape stripping on sweat gland function following occlusive application of 1096 aqueous AZAP.

ANTIPERSPIRANT ACTION OF ALUMINUM SALTS 71 Table I The Effect of Scotch © tape Stripping on Sweat Gland Function Following Occlusive Treatment with 20% ACH • • q- S.E. Median Percentage of glands inhibited 95 + 2 98 Percentage of inhibited glands restored to firing 51 _+ 6 50 •N = 25 subjects For example, if the pre-treatment, post-treatment, and post-stripping values were 100, 20 and 40 respectively, then 40- 20 20 -- X 100 = 25% of the inhibited glands were restored to firing. 100- 20 80 RESULTS For the subjects studied, the number of sweat gland droplets in an experimental site prior to treatment ranged from about 100 in the less dense proximal areas to as many as 500-600 in the heavily populated distal areas. Most subjects, however, had an average of 200-300 sweat glands per site. The effect of Scotch © tape stripping on these sites subsequent to their overnight occlusive treatment with either 20% ACH, 10% AZAP or 8% A1CI 3 was as follows. ACH The occlusive application of 20% ACH resulted in virtually total inhibition of sweat gland function, with only 5% of the treated glands able to fire under thermal stress (Table I). After Scotch tape stripping away the stratum comeurn layer of the skin, however, half the number of those glands which had been inhibited were now restored to normal firing. AZAP As had been seen for ACH, the overnight occlusive application of AZAP also resulted in nearly total inhibition of sweat gland function. The effect of stripping on these glands resulted in restoration, on average, of two-thirds of them to function (Table II). Table II The Effect of Scotch © tape Stripping on Sweat Gland Function Following Occlusive Treatment with 10% AZAP • • q- S.E. Median Percentage of glands inhibited 93 -+ 2 97 Percentage of inhibited glands restored to firing 67 + 9 66 •N = 25 subjects