Table Mean Wrinkle Grade Variation With Age (mean± SD) at Different Skin Sites (Caucasian) ---II Corner of Age group Forehead Glabella Upper eyelid the eye Lower eyelid N asolabial groove Cheek 20-29 2.50 ± 0.89 2.06 ± 1.06 1.86 ± 0.66 2.06 ± 0.68 3.25 ± 0.58 2.56 ± 0.73 2.25 ± 0.68 30-39 3.00 ± 1.00 3.05 ± 0.97 2.89 ± 0.90 3.14 ± 0.65 3.81 ± 0.68 3.19 ± 0.68 3.14 ± 0.73 40--49 3.88 ± 0.70 3.88 ± 0.70 3.50 ± 1.00 3.88 ± 0.60 4.65 ± 0.49 3.71 ± 0.99 3.65 ± 0.49 50-59 4.13 ± 0.83 3.87 ± 0.74 3.91 ± 0.83 4.00 ± 0.76 4.47 ± 0.64 4.33 ± 0.72 3.87 ± 0.74 60-69 3.81 ± 0.98 4.19 ± 0.66 4.36 ± 0.63 4.44 ± 0.51 4.88 ± 0.34 4.69 ± 0.60 4.56 ± 0.63 Average 3.44 ± 1.06 3.39 ± 1.12 3.25 ± 1.18 3.48 ± 1.03 4.19 ± 0.81 3.66 ± 1.05 3.47 ± 1.00 Correlation coefficient r = 0.516 r = 0.655 r = 0.762 r=0.769 r = 0.681 r = 0.711 r = 0.755 p 0.001 p 0.001 p 0.001 p 0.001 p 0.001 p 0.001 p 0.001 Corner of the mouth 2.25 ± 0.45 3.00 ± 0.71 3.76 ± 0.75 4.27 ± 0.80 4.69 ± 0.48 3.55 ± 1.07 r = 0.808 p 0.001 \..),) ---....J 0\ '-i 0 C � z � 0 rTj Ci 0 (FJ � b1 ,.., - Ci (FJ Ci - b1 z Ci b1

Table III Mean Wrinkle Grade Variation With Age (mean± SD) at Different Skin Sites Qapanese) --- Corner of Age group Forehead Glabella Upper eyelid the eye Lower eyelid Nasolabial groove 20-29 1.79 ± 0.70 1.21 ± 0.43 1.29 ± 0.47 1.21 ± 0.43 1.71 ± 0.47 1.57 ± 0.65 30-39 2.43 ± 0.94 1.86 ± 0.66 2.00 ± 0.55 2.07 ± 0.83 2.43 ± 0.51 2.21 ± 0.58 40--49 2.86 ± 0.86 2.93 ± 0.92 2.79 ± 0.80 2.86 ± 0.53 3.07 ± 0.47 3.00 ± 0.96 50-59 3.57 ± 1.02 2.86 ± 0.86 3.50 ± 0.65 3.50 ± 0.52 3.86 ± 0.66 3.29 ± 0.73 60-69 4.43 ± 0.76 4.14 ± 0.95 4.36 ± 0.50 4.14 ± 0.36 4.50 ± 0.52 4.50 ± 0.52 Average 3.01 ± 1.25 2.60 ± 1.27 2.79 ± 1.24 2.76 ± 1.17 3.11 ± 1.12 2.91 ± 1.21 Correlation coefficient r = 0.766 r = 0.801 r = 0.898 r = 0.911 r = 0.892 r = 0.842 p 0.001 p 0.001 p 0.001 p 0.001 p 0.001 p 0.001 Cheek 1.14 ± 0.36 1.64 ± 0.50 2.57 ± 0.51 3.14 ± 0.53 3.64 ± 0.50 2.43 ± 1.04 r = 0.889 p 0.001 Corner of the mouth 1.14 ± 0.36 1.86 ± 0.66 2.57 ± 0.51 3.50 ± 0.52 3.93 ± 0.47 2.60 ± 1.15 r = 0.910 p 0.001 � b1 � b1 s: f---1 b1 u rTj n - � � � - z � - z � \..),) -...._J -...._J