(A)
MMP-
(B)
100
OJ 8)
0:::
·vi
BJ
.40
0:::
JJ
ANTI-AGING COMPOUNDS FROM JEJU ISLAND
NcmSNP SNP TO PHA PHY FG CA NT CJ EGCG
31
Figure 4. The expression of MMP-1 in human fibroblasts (ATCC, CRL-207 6). All plant extracts were used
at 100 µg/ml, except EGCG (25 µM). Non-SNP: in the absence of sodium nitroprusside. SNP: in the
presence of sodium nitroprusside. TO: Typha orientalis (seed). PHA: Pyrrosia hastata (root). PHY: Persicaria
hydropiper (whole plant). FG: Filipendula glaberrima (root). CA: Capsicum annum (whole plant). NT: Nymphaea
tetragona (rhizome). CJ: Camellia japonica (leaf). EGCG: (-)epigallocatechin-3-gallate.
of its small area. We searched for plants with effective anti-aging compounds for the skin
among the natural plants of Jeju Island.
Sixty plants from Jeju Island were extracted, and their activities were investigated for
free radical scavenging activity, elastase inhibition activity, and reduction of the expres-
sion of MMP-1 mRNA related to collagenase, which is known to degrade collagenase
and induce wrinkling of the skin. As a result, we found twelve plants with highly effective
DPPH radical scavenging activity and seven plants with good anti-elastase activity. Five
of the seven species with superior effects on elastase activity inhibition also had high
DPPH radical scavenging activity, which suggests that there is a certain correlation
between the causes of the two activities. When comparing the inhibition activities of the
seven extracts on MMP-1 expression in human fibroblasts with EGCG as a positive
control, four extracts, Persicaria hydropiper (whole plant), Filipendula glaberrima (root),
MMP-
(B)
100
OJ 8)
0:::
·vi
BJ
.40
0:::
JJ
ANTI-AGING COMPOUNDS FROM JEJU ISLAND
NcmSNP SNP TO PHA PHY FG CA NT CJ EGCG
31
Figure 4. The expression of MMP-1 in human fibroblasts (ATCC, CRL-207 6). All plant extracts were used
at 100 µg/ml, except EGCG (25 µM). Non-SNP: in the absence of sodium nitroprusside. SNP: in the
presence of sodium nitroprusside. TO: Typha orientalis (seed). PHA: Pyrrosia hastata (root). PHY: Persicaria
hydropiper (whole plant). FG: Filipendula glaberrima (root). CA: Capsicum annum (whole plant). NT: Nymphaea
tetragona (rhizome). CJ: Camellia japonica (leaf). EGCG: (-)epigallocatechin-3-gallate.
of its small area. We searched for plants with effective anti-aging compounds for the skin
among the natural plants of Jeju Island.
Sixty plants from Jeju Island were extracted, and their activities were investigated for
free radical scavenging activity, elastase inhibition activity, and reduction of the expres-
sion of MMP-1 mRNA related to collagenase, which is known to degrade collagenase
and induce wrinkling of the skin. As a result, we found twelve plants with highly effective
DPPH radical scavenging activity and seven plants with good anti-elastase activity. Five
of the seven species with superior effects on elastase activity inhibition also had high
DPPH radical scavenging activity, which suggests that there is a certain correlation
between the causes of the two activities. When comparing the inhibition activities of the
seven extracts on MMP-1 expression in human fibroblasts with EGCG as a positive
control, four extracts, Persicaria hydropiper (whole plant), Filipendula glaberrima (root),
