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J. Cosmet. Sci., 72, 33–45 (January/February 2021) 33 Skin Penetration of Hazardous Air Pollutants in Presence of Antipollution Cosmetics SORAYA PONTES-LÓPEZ, ANA GONZÁLVEZ, FRANCESC A. ESTEVE-TURRILLAS, and SERGIO ARMENTA, Department of Analyt ical Chemistry, University of Valencia, Burjassot 46100, Spai n (S.P.-L., F.A.E.-T, S.A.), RNB, Cosmetic Laboratory, Industrial Estate La Pobla-L’Eliana, La Pobla de Vallbona 46185, Spain (A.G.) Accepted for publication September 29, 2020. Synopsis Different a n tipolluti on products have recently irrupted the market to answer current health concerns related to air contamination. Thus, the development of methodologies for the appropriate evaluation of the effi cacy of these products is needed. In this study, an appropriate analytical methodology has been developed and validated for the evaluation of the effectiveness of antipollution cosmetic products against the dermal absorption of different hazardous air pollutants (HAPs). In vitro vertical Franz diffusion cells and Strat-M® as human skin simulants have been used to assess the effectivity of antipollution cosmetic products. An exposition chamber, with a fi xed and constant concentration of HAPs, including benzene, toluene, ethylbenzene, and xylene isomers, chlorobenzene, nitrobenzene, haloalkanes, and polycyclic aromatic hydrocarbons, has been designed and made to simulate contaminated atmospheres. The effi cacy of antipollution cosmetic products has been evaluated using a multi-pollutant approach, representing a more stringent situation. Diffusion parameters, including fl ux and lag time, have been calculated for HAPs in the presence of cosmetic samples, using 2 mg product per cm2, and in control tests. The behavior of HAPs followed Fick’s fi rst law, allowing the calculation of diffusion parameters. Antipollution effectiveness is demonstrated by statistical evaluation of the diffusion parameters obtained for controls and cosmetics samples. So, a reduction in fl ux values and an increase in lag times imply an appropriate antipollution effectiveness. INTRODUCTION Air poll ution is one of the major concerns of 21st century society because of the risk- associated adverse effects on human health (1). Air pollutants can be classifi ed in two main types: (i) criteria air pollutants, which include ozone, carbon monoxide, particulate mat- ter, lead, sulfur, and nitrogen dioxides and (ii) hazardous air pollutants (HAPs), related to source-specifi c emissions, which include more than 150 compounds (2). HAPs are Address all correspondence to Sergio Armenta at sergio.armenta@uv.es.