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J. Cosmet. Sci., 72, 63–80 (January/February 2021) 63 Identifi cation of the Underlying Genetic Factors of Skin Aging in a Korean Population Study JUNG OH KIM, BOREUM PARK, JOUNG YOON CHOI, SO RA LEE, SO JIN YU, MYEONGJIN GOH, HAEKWANG LEE, WON-SEOK PARK, IN SOO SUH, DAE-SEUNG KOH, and KYUNG-WON HONG , Theragen Etex Bio Institute Co. Ltd., Suwon 16229, Republic of Korea (J.O.K., B.P., J.Y.C., S.R.L., S.J.Y., K.W.H.), Amorepacifi c R&D Center, Amorepacifi c Corporation, Yongin 17074, Republic of Korea (M.G.), P&K Skin Research Center, Yeongdeungpo-gu, Seoul 07236, Republic of Korea (H.L., W.-S.P.), Bio-Convergence Center, Jeju Technopark, Jeju 63243, Republic of Korea (I.S.S., D.S.K.) Accepted for publication October 2, 2020. Synopsis Genetic polymorphisms may affect the molecular mechanisms underlying determination of skin type. So far, several genetic studies have been reported however, very few studies have been conducted to examine the relationship between genotype and skin phenotypes. In this study, the genome sequences of individuals tested for fi ve cosmetic characteristics (wrinkles, moisture content, pigmentation, oil content, and sensitivity) were determined, and we also conducted fi ve genome-wide association studies (GWASs) to identify predictive markers. Some single-nucleotide polymorphisms (SNPs) within those genes were more frequent in individuals exhibiting stronger traits. GWASs revealed that two genome-wide signifi cant SNPs within FCRL5 and OCA2 genes were associated with wrinkles and pigmentation, respectively (p 5 × 10-8), and that genome- wide SNPs in 21 genes (wrinkles: FCRL5, REEP3, ADSS, and SPTLC1 moisture: TBX4, TRPM3, CEMIP2, CTSH, and TTC39C pigmentation: OCA2, NCLN, TNS1, CDC42BPA, HS3ST4, and UNCX oil: SYN2, CNDP1, GAS6, INSR, and TNFRSF19 and sensitivity: CREB5) might be associated with fi ve skin phenotypes. Among these, a genome-wide signifi cant SNP (rs117381658) and the SNP located downstream of FCRL5, which encodes a member of the immunoglobulin receptor family, were associated with an increased risk of wrinkles (p = 1.52 × 10-8). The other genome-wide signifi cant SNP (rs74653330) was associated with a decreased risk of pigmentation (p = 1.04 × 10-8), which is located in the coding region of OCA2 that encodes for a transporter of melanin. Our study reports genetic factors associated with skin cosmetology parameters in the Korean population. We hope our fi ndings will provide a foundation for further genetic and molecular studies related to custom cosmetics. Based on these fi ndings, the industry will be able to provide consumers with ingredients capable of palliating the lack of function associated in genes with SNPs. INTRODUCTIO N Skin aging is recognized as a clinically observable alteration of mechanical and chromatic properties on the skin’s surface. In cosmetic dermatology, wrinkling is an obvious and Address all correspondence to Kyung-Won Hong at kyungwon.hong@theragenetex.com .