784 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS (10) Smyth, J. R., Porter, J. W., and Bohren, B. B., A study of pigments from red, brown and buff feathers and hair, Physiol. Zool., 24,205-216 (July 1951). (11) Barnicot, N. A.., The pigment, trichosiderin, from human red hair, Nature, 177, 528-529 (Mar. 17, 1956). (12) Flesch, P., Esoda, E. J. and Katz, S. A., The iron pigment of red hair and feathers, J. Invest. Dermatol., 47, 595-597 (December 1966). (13) Dutcher, T. F., and Rothman, S., Iron, copper, and ash content of human hair of dif- ferent colors, Ibid., 17, 65-68 (Aug. 1951). (14) Lowry, O. H., Rosebrough, N.J., lCarr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193,265-275 (November 1951). (15) Rothman, S., and Flesch, P., Isolation of an iron pigment from human red hair, Proc. Soc. Exptl. Biol. Med., 53, 134-135 (May-June 1943). (16) Fox, H. M., and Vevers, G., The Nature of Animal Colours, Sidgwick and Jackson Ltd., London, 1960, p. 33. (17) Bohren, B. B., Conrad, R. M., and Warren, D.C., A chemical and histological study of the feather pigments of the domestic fowl, Am. Naturalist, 77, 481-518 (November- December 1943). (18) Barnicot, N. A., and Birbeck, M. S.C., The Electron Microscopy of Human Melanocytes and Melanin Granules, in Montagna, W., and Ellis, R. A., Biology of Hair Growth, Academic Press, New York, N.Y., 1958, pp. 255-301. (19) El-Hefnawi, H., Shukri, A. S., and Rasheed, A., Kwashiorkor in the United Arab Re- public, Brit..1. Dermatol., 77, 137-150 (March 1965).

J. Soc. Cosmetic Chemists, 18, 785-796 (Dee. 9, 1967) Use of Electronic Data Processing in Anti-Dandruff Clinical Research MARTIN GREIF, B.S.,* and HARRY J. PROKOP• Presented November $0, 1966, New York City Synopsis--Fifteen different compositions were studied in a pilot clinical program in terms of their ability to control the symptoms of dandruff. The clinical protocol is discussed briefly. Electronic data processing of the double-blind monadic clinical study is described in some detail. For comparison purposes, the data were analyzed both by EDP and manual means. The relative economics are discussed. INTRODUCTION The etiology of dandruff and its treatment have been discussed in scores of technical communications during the past century. In an early scientific discussion of dandruff, Malassez (1) was the first to indict Pityrosporum ovale as the cause of dandruff. Over the years from 1874 to the present day, numerous authors have taken sides for or against this hypothesis. Each has presented evidence to support his contentions. The literature is replete with references (2-8) covering both sides of this controversy. A systematic review of the literature discloses that numerous addi- tional theories on the cause of dandruff have been offered, and countless treatment procedures were reported as being effective. Thus there are theories relating to various microbial causes (9-14). Wallace (15) con- siders dandruff to be a manifestation of seborrhea or psoriasis bearing no * Consumer Products Division, American Cyanamid Company, Wayne, N.J. 07470. t Fisher-Stevens, Clifton, N.J. 07012 785