STATISTICAL EVALUATION OF CUTANEOUS iRRITANTS 829 mentation in the design of patches and the techniques used in applying them is desirable. (4) It has frequently been felt that lack of uniformity in patch test responses is the result of a "pressure effect." This work has demonstrated that one of the greatest sources of variation is subject-to- subject variation, which is easily isolated by proper experimental designs, which in turn has the effect of sensitizing the experiment so that a given variable may be tested with a much smaller group of subjects than otherwise. Of course the use of small groups presupposes that they are a fair sample of the population to which the results are to be extrapolated. (Received February 14, 1967) (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (n) (i2) (13) (14) (15) (16) REFERENCES Schneiderman, M. A., Is it really bad? A proposal for the toxicity-testing of drugs, J. Soc. Cosmetic Chemists, 14,227-232 (1963). Schwartz, L., Dermatitis from new synthetic resin fabric finishes, .1. Invest. Dermatol., 4, 459-470 (1941). Shelanski, H. A., and Shelanski, M. V., A new technique for human patch tests, Proc. Sci. Sect. Toilet Goods Assoc., 19, 46-49 (1953). Draize, J., Procedures for the appraisal of chemicals in foods, drugs and cosmetics VIII Dermal Toxicity, Food Cosmetic Law J., 10, 722-732 (1955). Voss, J., Skin sensitization by mercaptans of low molecular weight, .L Invest. Dermatol., 31,273-279 (1958). Rostenberg, A., Cutaneous reactions from cosmetics, J. Soc. Cosmetic Chemists, 11,170- 178 (1960). Davies, O. W. (Editor), Design and Analysis of Industrial Experiments, 2nd ed., Hafner Publishing Co., Inc., New York, N.Y., 1962. Cochran, W. G., and Cox, G. M., Experimental Designs, 2nd ed., John Wiley & Sons, Inc., New York, N.Y., 1962. Goldstein, A., Biostatistics, The MacMillan Co., New York, N.Y., 1964. Snedeeor, G. W., Statistical Methods Applied to Experiments in Agriculture and Biology, 5th ed., The Iowa State University Press, Ames, Ia., 1962. Fisher, R. A., The Design of Experiments, 7th ed., Hafner Publishing Co., New York, N.Y., 1960. Bennett, C. A., and Franklin, N. L., Statistical Analysis in Chemistry and the Chemical Industry, John Wiley & Sons, Inc., New York, N.Y., 1963. Fisher, R. A., and Yates, F., Statistical Tables for Biological, Agricultural and Medical Research, 6th ed., Hafner Publishing Co., Inc., New York, N.Y., 1963. Cox, D. R., Planning of Experiments, John Wiley & Sons, Inc., New York, N.Y., 1958. Shefie, H., The Analysis of Variance, John Wiley & Sons, Inc., New York, N.Y., 1959. Kligman, A. M., and Wooding, W. M., A Method for the Measurement and Evaluation of Irritants on Human Skin, J. Invest. Dermatol. (publication expected in 1967).

Book Reviews PHARMACEUTICAL CHEMISTRY, VOL- UME I: THEORY AND APPLICATION, edited by Leslie G. Chatten, Marcel Dekker, Inc., New York. 1966. 504 pages, indexed. Price $14.50. The scope of this text can most ac- curately be described as analytical pharmaceutical chemistry. It is the first volume of a two-volume series which is intended as a text for senior undergraduate and graduate phar- macy students. It deals with theo- retical and practical considerations of gravimetric analysis, acid-base ti- trations and pH, precipitation and complex formation, acidimetry and alkalimetry, nonaqueous titrimetry, complexometric analysis, alkaloidal assay, miscellaneous methods, ion exchange, chromatography, and anal- ysis of fixed oils and volatile oils. Vol- ume II will cover the theory and ap- plication of instrumental techniques. This book is composed of thirteen chapters, each of which has been writ- ten by a different contributing au- thor. The joint authorship has an international character with contrib- utors from the United States, Canada, and England. Each of the authors is a teacher of pharmaceutical chemis- try or a related discipline of phar- macy. 831 Considering this organizational ap- proach, the material •vithin the book is surprisingly wdl presented and inte- grated. Only a slight tendency to- ward repetition is evident, and this is often justified for the sake of com- pleteness within each chapter. An ample number of references are listed at the end of each chapter for those interested in further pursuing a par- ticular topic. The reviewer believes that this book provides a significant advance over some previously available under- graduate texts in analytical pharma- ceutical chemistry in that emphasis has been placed on basic theory and applications of specific methods rather than on official assay proced- ures in the official compendia. The text helps to give insights into the of- ficial United States Pharmacopoeia and British Pharmacopoeia assay methods, but only as examples of the basic methods which are described in length. For individuals who have not been directly involved in analytical chem- istry, this book can serve as an excel- lent review and provides the opportu- nity to assimilate new methodology which has been added to the field in recent years.