ADULT AND CHILDREN'S HAIR 171 (22) Wolfram, L., and Lennhoff, M., The cystine content of hair: fiber-to-fiber variation, Textile Res. J., 37, 145 (1967). (23) Ogura, R., Knox, J. M., Griffin, A. C., and Kusuhara, M., The concentration of sulfhydryl and disulfide in hmnan epider•nis, hair and nail, J. Invest. Dermatol., 38, 69 (1962). (24) Eckstein, H. C., The cholesterol content of hair, wool, and feathers, J. Biol. Chem., 73, 363 (1927) Nicolaides, N., and Roth•nan, S., Studies in the che•nical cron- position of hmnan hair fat, J. Invest. Dermatol., 19, 389 (1952) Washburn, S. L., and Liese, G.J., The cholesterol content of hu•nan sebmn, J. Lab. Clin. Med., 41, 199 (1953). All in Rothman, S., Physiology and Biochemistry o[ the Skin, Univer- sity of Chicago Press, Chicago, II1., 1954. (25) Nicolaides, N., Chemical composition of hmnan hair fat, y. Invest. Dermatol., 21, 9 (1953). (26) Bean, R. B., Hair and eye color in old Virginians, Am. J. Phys. Anthropol., 20, 171 (1935). (27) Trotter, M., Classification of hair color, Ibid., 25, 237 (1939). (28) Steggerda, M., Change in hair color with age, f. Heredity, 402 (1941). (29) Garn, S. M., Human hair: Its composition, anatomy and distribution, Ph.D. thesis, Harvard University, April, 1948. (30) Gardner, B. B., and MacAdmn, D. L., Colori•netric analysis of hair color, Am. ]. Phys. Anthropol., 19, 187 (1934). (31) Flesch, P., and Roth•nan, S., Isolation of an iron pigment frown hmnan red hair, J. Invest. Dermatol., 6, 257 (1945). (32) Flesch, P., Esoda, E. J., and Katz, S., The iron pigment of red hair and feathers, Ibid., 47, 595 (1966). (33) Den Beste, M., A new reflectometer, in preparation.

J. Soc. Cosmetic Chemists, 20, 173-184 (March 4, 1969) Toxicological Properties Hexachlorophene of WILLIAM S. GUMP, Ph.D? Presented May 16, 1968, Filth IFSCC Congress, Tohyo, Japan Synopsis--Since the introduction of hexachlorophene as an antibacterial additive to soaps, detergents, and cosmetics about 20 years ago, a large number of toxicological studies have been carried out. These studies dealt with the systemic and the oral acute and sub- acute toxicity in laboratory animals, also with the toxic symptoms and deaths observed in cows and sheep where hexachlorophene is used for the control of fascioliasis. Reports on toxic effects in man and poisoning from improper use have also been published. The cutaneous tolerability of hexachlorophene has been thoroughly investigated tests relating to primary irritation, sensitization, and photosensitization have been carried out on experimental animals and on humans. The limitations of laboratory and clinical tests and the importance of establishing safety by the actual use of products containing hexachlorophene by a large number of persons over long periods of time are emphasized. INTRODUCTION Since the synthesis of hexachlorophene •- in 1939 (1) and its com- mercial introduction after World War II, especially as an antibacterial additive to soaps (2), much data on the toxicology of this compound has accumulated. Some of the data are found in papers of American and foreign investigators other data are the results of studies initiated by us, most of which have not been published. It seemed worthwhile to compile all the pertinent data and present here a summary of the properties of hexachlorophene in regard to its oral, systemic, and dermal toxicity. • Givaudan Corp., 321 West 44th St., New York, N.Y. 10036. •'G-11 ©, tradename of Givaudan Corp. and formerly of Sindar Corp., a subsidiary of Givaudan Corp. 173