JOURNAL OF COSMETIC SCIENCE The Application of Thermosensitive Polymers to Liquid Plaster Shiro Nakai, Yasuko Mori, Satoru Yoshino Products Development Division, Rohto Pharmaceutical Co., Ltd. 1-8-1, Tatsumi-Nishi, Ikuno-ku, Osaka 544- 8666, Japan Liquid plasters, dissolved pyroxylin (nitrate ester of cellulose) in organic solvents, are classified as new quasi drugs or OTC drugs, which are used for the purpose of dressing damage and disinfection. The defects are the odor of the organic solvents, strong irritation against damaged skin, difficulty at the removal of formed film, and poor release of active ingredients from plasters. A thermosensitive polymer was prepared by co-polymerization of N-isopropyl acrylamide and n-butyl methacrylate. The application of the thermosensitive polymer to liquid plaster improved the above defects, and showed formation of appropriate firm and effective antimicrobial activities. The Application of Sodium Dextran Sulfate to the Field of Cosmetics Ichiro Kato Nagoya Research Laboratory, MEITO SANGYO Co., Ltd. 25-5, Kaechi, Nishibiwajima, Kiyosu 452-0067, Japan In this study, it was shown that sodium dextran sulfate (OS), which is used as an antihyperlipoproteinemic and is clinically known for the improvement of the blood flow, accelerated nitric oxide (NO) synthesis in the normal human epidermal keratinocytes. Currently, the free radical NO is known to be an important mediator in various physiological and pathophysiological processes of the skin, such as regulation of blood flow. The result suggests that OS might exert improvement on the blood flow by the acceleration of NO synthesis. The evaluation in the human body test showed that OS effectively reduced and prevented the swelling of the lower leg. Consequently, it is reasonable to suggest that OS could penetrate into the epidermis and enhance NO synthesis, and NO released from the epidermal keratinocytes could promote the blood flow in the microvasculature and reduce the swelling of the lower leg. Molding Technology and Quality Estimation on the Lipstick Production Scene Hiroshi Fukasawa Production Technology Section Kumagaya Plant ALBION Co., Ltd. 4-1-1, Funakidai, Kumagaya 369- 0108, Japan In this paper, the optimization of a generic function of a lipstick manufacturing process is discussed. Traditionally, the quality of lipsticks has been measured by objective quality characteristics such as appearance. Sensory tests, which are not recommended in quality engineering, had been used to evaluate such quality characteristics. That is because these quality characteristics are not stable due to the changes of environmental conditions such as between-lot variability and seasonal variation. When such quality problems occurred, manufacturing conditions were adjusted from time to time, which is known as fire fighting or "mole beating" in Japanese. Among those objective quality characteristics, the ones such as scratches, color uniformity or breaking during usage are manufacturing related. As a generic function, the stress/strain relationship was investigated and the results showed that the relationship has satisfied Hook's Law with a good improvement. Vol. 40, No. 3, 2006 Flow-Ifljection Analysis with Photometric Detection for the 5.0 X 10 -2 mol/L phosphate buffer solution were pumped Screening ofTyrosinase Inhibitors into the analytical line at a constant flow rate. An aliquot of the tyrosinase solution containing an inhibitor was injected Kazuki Kageshima, Kenji Okada, Yoshiya Ishihara, Toshiyuki Shimizu Haohiohji Laboratory, Utena Co., Ltd., 575-3, Kitano­ machi, Hachiohji 192-0906, Japan A rapid and simple method for the screening of tyrosinase inhibitors based on a flow-ifljection analysis (FIA) method using a spectrophotometric detector is described. An aqueous solution of L-DOPA (5.0xlO -3 mol/L) and a into the phosphate buffer stream by a loop-valve injector, and then it was fed to the spectrophotometric detector through the reaction coil. The absorbance of reaction products was monitored at 475nm As a result, the peak height of the flow signal was proportional to the enzyme activity unit, ranging from I unit/ml, to 10 units/ml� (r= 0.992). The FIA system could measure a sample within 5 min. B -Arbutin, L-ascorbic acid, and caffeic acid showed strong inhibition for tyrosinase activity in the method described here.

ABSTRACTS 497 Measurement Study on Male Skin Damage Caused hy reason why high moisturizer content generates strong Electric Shavers stickiness is that the polar group of the molecule is exposed to the surface. Thus, we began with the hypothesis that Manami Kuruto, Mi yu ki Shiohara, Kaoru Suganuma stickiness could be prevented through coexistence with a substance minimizing the exposure of the polar group. FCG Research Institute, Inc., Fuji Television Bid. ANNEX Using glycerin as a moisturizing agent, we screened a large 6F, 3-32-42, Higashi-Shinagawa, Tokyo 140-0002, Japan Shinagawa-ku, number of conventional materials for reducing stickiness but failed to find an effective compound. We then considered the use of a polymer for this purpose, and Shaving is one of the daily tasks for most men. However, shaving has caused damage to the skin in many cases. In this study, we observed the skin and beards of21 men aged from 24 to 62 yr and investigated the influence on the skin and the peiformance of shaving using three models of electric shavers. As the result, it was found that subjecL� who have a thicker beard or subjects who take a longer time for shaving tend to have dry skin, rough skin and skin with pigmented spots. On comparison of the three models of electric shavers, one rotary shaver had few instances of TEWL and bleeding. The rotary shaver was the gentlest to the skin of the three models. The other two models were swing shavers. On sensory evaluation, "sharpness of the three models" and "a feeling of close shave" tended to have a linear relation with increase in TEWL and increase in redness. Then it was observed that it is easy to misunderstand the burden on skin with good shaving perfonnance. A� it was revealed that the rough skin of a man is mainly caused by shaving in this study, the importance of shaving and skin care to reduce the hurden on the skin was shown. synthesized a custom-made polymer, polyglycolmethacrylate-2-hydroxyethylmethacrylate­ fluoroalkylacrylate copolymer (Polymer SR). Our experiments revealed that Polymer SR reduces the stickiness of glycerin by forming a hydrophobic film without hindering moisturizing petformance. To clarify the mechanism by which Polymer SR restrains stickiness, we investigated the interaction between the Polymer SR and glycerin in solution form with NNIR and static light­ scattering measurements. We learned that Polymer SR and glycerin exist on skin as the hydrophobic group of Polymer SR orients to the outside. Subjective sensory test� supported our belief that this hydrophobic orientation is maintained on the dermal surface even after application to the skin. We believe that our technique for restraining the stickiness of moisturizers can be adopted for use with other substances by taking into account the intended function and feel, and will contribute to future cosmetic research. Studies on Decomposition by Heating of Blue No. 1 (Brilliant Blue FCF) in an Alkaline Solution Simultaneous Enhancement of Cosmetic Function and Feel Sumiko Tsuji, Hiroshi Tokunaga via Molecular Investigation of Stickiness Hiroki Kudoh"'2, Hirokazu lyanagi"'3, Kenichi Yoshizawa"'4, Sayuri Okura"'2, Katsuhiko Nakamae"'5 Skincare Products R&D Department"'2, Makeup Products R&D Departrnent"'3, POLA Chemical Industries, Inc., 27- 1, Takashimadai, Kanagawa-ku, Yokohama 221-0833, Japan - Quality Design & Assurance R&D Department"'4, POLA Chetnical Industries, Inc., 560, Kashio-cho Totsuka­ ku, Yokohama 224-0812, Japan - Japan Synchrotron Radiation Research Institute"'5, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo 675-5198, Japan Moisturizing performance is often a very i mp ortant factor in cosmetics. However, incorporating high concentrations of moisturizing agents often causes products to become sticky, a feel that consumers dislike. We suspected that the National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan It is known that Blue No. I (Bl brilliant blue FCF) in an alkaline solution can be decomposed on heating. However, it is also known that the color tone of Bl when in alkaline solution fonn does not change at room temperature. In this study, the heating decomposition of Bl in an alkaline solution was examined using liquid chromatography/mass spectrometry (LC/MS) and HPLC. As a result, the generation of ethylamino subsidiary (Blsub-EA) and phenol subsidiary (Blsub-HP) colors that existed in commercial BI were confirmed. The generation of B 1 sub­ EA was very limited, and most of the decomposition of Bl was Bl sub-HP that showed in a purplish-red color. It had been suggested that Blsub-HP should change into an oxocyclohexadienyli dene subsidiary color (B 1 sub-OCD)