JOURNAL OF COSMETIC SCIENCE 88 our patients wished to continue using the product after the 1-mo period. Future research should follow the cohort for longer than 1 mo to uncover whether longer use of this prod- uct could result in potentially better outcomes. Last, some may argue that the formulation’s moisturizing vehicle by itself could induce enhanced moisturization of the skin and improve the appearance of SD. Future studies should use a split study of our formulation versus a placebo moisturizer. CONCL USION This study demonstrates that the investigated topical formulation is safe and effective to use for SD. It can help improve the appearance and texture of SD. It may also be consid- ered for use in helping to prevent SD, as prior evidence supports the use of topical creams in preventing the formation of new SD, especially in pregnant women. Autho r Disclosure: Christopher I. Zoumalan, MD, owns stock and is the scientifi c advisor for MD Medical Designs, Inc., Los Angeles, CA, manufacturer of the stretch mark cream used in this study. ACKNO WLEDGMENT We th ank Cristina Luna for her research-coordinating support. REFER ENCES (1) A . L. S. Chang, Y. Z. Agredano, and A. B. Kimball, Risk factors associated with striae gravidarum, J. Am. Acad. Dermatol., 51(6), 881–885 (2004). (2) K. H. Kelekci, S. Kelekci, E. Destegul, A. Aksoy, N. Sut, and B. Yilmaz, Prematurity: is it a risk factor for striae distensae? Int. J. Dermatol., 50(10), 1240–1245 (2011). (3) A. Hague and A. Bayat, Therapeutic targets in the management of striae distensae: a systematic review, J. Am. Acad. Dermatol., 77(3), 559–568 (2017). (4) B. J. Kim, D. H. Lee, M. N. Kim, K. Y. Song, W. I. Cho, C. K. Lee, and O. S. Kwon, Fractional pho- tothermolysis for the treatment of striae distensae in Asian skin, Am. J. Clin. Dermatol., 9(1), 33–37 (2008). (5) S. Kang, Topical tretinoin therapy for management of early striae, J. Am. Acad. Dermatol., 39(2), S90– S92 (1998). (6) M. C. A. Issa, L. E. de Britto Pereira Kassuga, N. S. Chevrand, L. do Nascimento Barbosa, R. R. Luiz, L. Pantaleão, E. G. Vilar, and M. C. Rochael, Transepidermal retinoic acid delivery using ablative frac- tional radiofrequency associated with acoustic pressure ultrasound for stretch marks treatment, Laser Surg. Med., 45(2), 81–88 (2013). (7) S. Guida, M. G. Galimberti, M. Bencini, G. Pellacani, and P. L. Bencini, Treatment of striae distensae with non-ablative fractional laser: clinical and in vivo microscopic documentation of treatment effi cacy, Laser Med. Sci., 33(1), 75–78 (2018). (8) V. Mishra, L. Miller, S. M. Alsaad, and E. V. Ross, The use of a fractional ablative micro-plasma radio- frequency device in treatment of striae, J. Drugs Dermatol. JDD, 14(11), 1205–1208 ( 2015). (9) H. Bak, B. J. Kim, W. J. Lee, J. S. Bang, S. Y. Lee, J. H. Choi, and S. E. Chang, Treatment of striae distensae with fractional photothermolysis, Dermatol. Surg., 35(8), 1215–1220 (2009). (10) F. Malekzad, S. Shakoei, A. Ayatollahi, and S. Hejazi, The safety and effi cacy of the 1540nm non-ablative fractional XD probe of star lux 500 device in the treatment of striae alba: before-after study, J. lasers Med. Sci., 5(4), 194 (2014).
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