J. Cosmet. Sci., 71, 385–397 (November/December 2020) 385 A Topical Depigmentation Program Against Hyperpigmentation Enhances the Benefi ts of Previously Performed Chemical Peeling Procedures of the Face MAURIZIO CAVALLINI, FABIO MONTANARO, and MARCO PAPAGNI , Unit of Dermatology and Dermatosurgery, CDI Hospital, Milan 20124, Italy (M.C., M.P.), Statistics and Data Management Unit, Latis S.r.l., Genova 16121, Italy (F.M.) Accepted for publication June 16, 2020. Synopsis Chemical peeling can reduce skin hyperpigmentation however, once exhausted its thinning action, the depigmentation process does not continue further. We carried out a monocentric, prospective, noncontrolled study aimed at the evaluation of the effi cacy, safety, ease of use, pleasantness, and tolerability of a depigmentation topical treatment program in women submitted to a previous chemical peeling. The topical treatment has been administered daily for 30 days to 16 women submitted to a chemical peeling containing a fi xed-dose combination of salicylic acid, pyruvic acid, and retinoic acid within 7 days before study inclusion. Target skin areas have been evaluated for melanin concentration and skin texture before peeling and at study visits 1 (after peeling) and 2 (after the 30-day treatment). The topical treatment program induced a decrease in melanin concentration between study visits 1 and 2 (-4.74% p = 0.0008). It reduced melanin concentration even further between the prepeeling period and visit 2 (-7.8% p 0.0001). Patients rated the depigmentation topical treatment program as “very simple” (87.5%) and “simple” (12.5%) to use and as “pleasant” (56.25%) and “very pleasant” (43.75%). Results support the use of the home-based depigmentation topical treatment program to potentiate the effectiveness of a previous chemical peeling in hyperpigmentation reduction. I N TRODUCTION C utaneous pigment disorders can affect both genders, with prevalence among female subjects, and with different etiology. Pigment disorders can cause an aesthetic discomfort that, in many cases, is quite relevant, representing a persistent psychosocial burden for the patient (1). Hyperpigmentation consists of localized dark skin patches caused by qualitative and quantitative alterations in pigment distribution. Cutaneous pigment dis- orders can be classifi ed as hypermelanosis, that is, an increased or altered distribution of the pigment melanin in the epidermis and/or dermis, and as endogenous or exogenous hyperchromia (e.g., due to accumulation of nonmelanin pigments, such as hemosiderin, a granular pigment derived from ferritin bilirubin, an orange–yellow pigment normally Address all correspondence to Marco Papagni at dottmarcopapagni@gmail.com.