LANOLIN DERIVATIVES IN PRESSURIZED FORMULATIONS II 35 Table IV Propellant systems Propellant systems K L M N O P Q 3verall total 77 92 72 53 139 145 120 kverage 25.7 30.7 24 17.7 46.3 48.3 40 Table V Appearance of controls after 6 weeks Propellant system 20øC 0øC 0øC + 24 hours at 20øC K 1 1 1 L 1 1 1 M 1 1 1 1N' 1 1 1 O 1 1 1 P 1 5 5 (irreversible) Table VI Effect of shaking (on separated matter) after 6 weeks' storage. Propellant systems Lanolin 20øC 0øC + 24 hours at 20øC products K L M N O P Q K L M N O P Q i ii iii iv v vi vii ... VIIi ix x «f «f - - x x x .... 1 i 1« - x x - • « If .... 1 x i - 2f - - • II i .... 1 1 If xf xf lif II li II x xf xf xf li f llf li lif lif lif- x x • li II li - x x llf x - - x 1 li If II - x i .... i - 2f 2f - x 1 x .... i i i 2f i f If llf 2f 2f 2f •if xf If If 4f xf 4 Key: f = foaming inside container after shaking. x = separated matter does not redisperse. Separated matter redisperses. 1- = Stability of 25 seconds. i = ,, ,, i minute. 1 = ,, ,, 1 minute. l i = ,, ,, li minutes. 2 = ,, ,, 2 minutes. 4 = ,, ,, 4 minutes.

36 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS SUMMARY After 1 hour at 20øC Liquid parajfin, B.P. (Systems K-N Table I) The solubility of the lanolin products is fair to good, with the exception of alcohol solution lanolin (iv), water soluble lanolin "75" (ix), and water soluble wool alcohols "20" (x). The addition of industrial methylated spirits effects complete solution of all products, with the somewhat sur- prising exception of water soluble lanolin "75" (ix). The different effects of the various propellant systems are not as marked as might have been expected from the results obtained previously (1). In two instances--wool alcohols, B.P. (ii) in the propellant 12/liquid paraffin, B.P. system (K), and liquid lanolin "L.I.N." (viii) in the propellants 11/12/liquid paraffin, B.P. system (M), the results are contrary to expectation. Water (Systems O-Q Table I) The solubility of the lanolin products is poor in the water-based systems with the exception of water soluble lanolin "75" (ix), and water soluble wool alcohols "20" (x), but even the last two products are not completely soluble. The system containing propel/ant 114 (P) is inferior to that containing propel/ant 12 (0) with only one product, wool a/cohols, B.P. (ii). Replacing the halogenated propellants with butane does not have a con- sistent effect. With three products--wool alcohols, B.?. (ii), alcohol soluble lanolin (iv), and liquid lanolin "L.I.N." (viii), the solvent power of system Q (butane/IMS/water) is superior to that of system 0 (propellant 12/IMS/water) and system P (propellant 114/IMS/water). With two products, liquid lanolin "ISO" (vi) and liquid lanolin "R.I.C.2" (vii), its solvent power is inferior to those of systems 0 and P. With four of the products its solvent power is equal to those of systems 0 and P, and with one product, anhydrous lanolin, B.P. (i) its solvent power is equal to that of system 0 which in turn is superior to that of system P. Storage for 6 weeks at 20øC Liquid parajfin, B.P. (Systems K-N Table II) The solvent power of these systems has decreased somewhat. Some. changes in solubility of the lanolin products have occurred, notably with anhydrous lanolin, B.P. (i), with wool alcohols, B.P. (ii), and with liquid lanolin "A.C.E." (iii). The solubility of liquid lanolin "R.I.C.2" (vii) in the propellant 114/liquid paraffin B.P. system (L) has improved on storage.