56 JOURNAL OF COSMETIC SCIENCE
optical parameter for skin complexion perception. By framework among the said lipids, is one of new bio-lipids
artificially creating different optical environments and which have begun to be studied in terms of
varying ADa/ ADs from 10% to 200%, we found that skin physicochemical/biological properties and applicabilities.
appeared more beautiful when ADa/ ADs was in the 100- Sphingomyelin is known as a representative
125% range. We therefore considered methods for applying sphingophospholipid. In this study, we tried to use this
these results into the development of cosmetic products.
Investigation and testing of many different pigments
resulted in the development of specially-desi
gn ed
po wdered fiber with a #-shaped cross section dyed
magenta. An experimental foundation with this
po wdered
fiber produced a clear reflectance dip by raising reflectance
in the short and long wavelength ranges. ADa/ ADs
increased from 49% to 107% without reducing lightness
when this makeup foundation was applied on sallow skin.
Evaluation of a Novel Hybrid Polymer in Hair Treatment
Sakiko Uchida, Natsuko Hayashi, Nobuyuki Goto, Sueko
Daikai, Ayako Koyanagi, Masato Yoshioka
sphingomyelin as a cosmetic ingredient, particularly for a
li
po somal formula consisting of the sphingomyelin As a
result, it was found that its barrier (occlu ive) ability
against water eva
po ration was superior to that oflecithin as
a representative glycerophospholipid, due to a higher
rigidity in the bilayer membrane of the li
po some.
Therefore, it is expected that sphingomyelin will show a
complementary effect for damaged intercellular lipid
structures of the stratum corneum when it is applied to skin
care products. In addition, it was demonstrated that a skin
care product with sphingomyelin had a high
moisturizing/emollient ability and an improvement effect
on existing wrinkles.
SEIWA KASEI Co., Ltd., 1-2-14, Nunoichi-cho, Trend on Alternative to Animal Testing
Higashiosaka 579-8004, Japan
Hajime Kojima
Hydrolyzed proteins and silicones have been widely used
and played an important role in hair treatment. Effects on Japanese Center for the Validation of Alternative Methods
hair, of a newly developed hybrid
po lymer consisting of (JaCVAM), Division of Pharmacology, Biological Safety
hydrolyzed protein, alkyl chain and silicone was Research Center, National Institute of Health Sciences 1-
investigated. It was clear that the polymer was effective in 18-1, Kamiyouga, Setagaya-ku, Tokyo 158-8501, Japan
preventing dyed hair from discoloring and in i
mp roving the
moisture feel of hair. It was confirmed that the
po lymer had
good substantivity contributing to hair luster,
manageability, moisture feel, smoothness and good
combability. The above effects were remarkably displayed
especially on damaged hair. Furthermore, a sensory test in
practical use of shampoo even with the polymer highly
diluted supported the above results.
For the promotion of 3R's (Reduction, Refinement,
Replacement) principles of animal tests, the EU and US
established the European Center for the Validation of
Alternative Methods (ECVAM) and the Interagency
Coordinating Committee on the Validation of Alternative
Methods (ICCVAM), respectively. The purpose of these
centers is to detect reliability and relevance of alternative
methods, which should be determined by intra- and inter-
laboratory validation and peer review for their regulatory
Stabilization and Application of Li
po somal Structures acceptance. A similar institute was established in Japan, the
Containing Sphingomyelin Japanese Center for the Validation of Alternative Methods
(JaCVAM) in the National Institute of Health Sciences
Chihiro Kaise, Teruhisa Kaneko (NIHS). However, there are not enough resources in Japan.
It is necessary to cooperate with a Japanese science society
R&D Control Department, SHU UEMURA Inc., 5-7-17, like the Japanese Society of Alternatives to Animal
Minami Aoyama, Minato-ku, Tokyo 107-0062, Japan Experiments (JSAAE) and a Japanese industry group like
the Japanese Cosmetic Industry Association (JCIA). We are
Cosmetic products with high affinity to the skin have been expecting JaCVAM to contribute to the validation and peer
recently studied, applying liposome and nano-sized review of new alternative methods with supporters and
capsules formed by amphiphiles such as lecithin and other international cooperation for the evaluation of the safety of
lipids to them. Sphingolipid, based on the sphingosine cosmetic ingredients and products.
optical parameter for skin complexion perception. By framework among the said lipids, is one of new bio-lipids
artificially creating different optical environments and which have begun to be studied in terms of
varying ADa/ ADs from 10% to 200%, we found that skin physicochemical/biological properties and applicabilities.
appeared more beautiful when ADa/ ADs was in the 100- Sphingomyelin is known as a representative
125% range. We therefore considered methods for applying sphingophospholipid. In this study, we tried to use this
these results into the development of cosmetic products.
Investigation and testing of many different pigments
resulted in the development of specially-desi
gn ed
po wdered fiber with a #-shaped cross section dyed
magenta. An experimental foundation with this
po wdered
fiber produced a clear reflectance dip by raising reflectance
in the short and long wavelength ranges. ADa/ ADs
increased from 49% to 107% without reducing lightness
when this makeup foundation was applied on sallow skin.
Evaluation of a Novel Hybrid Polymer in Hair Treatment
Sakiko Uchida, Natsuko Hayashi, Nobuyuki Goto, Sueko
Daikai, Ayako Koyanagi, Masato Yoshioka
sphingomyelin as a cosmetic ingredient, particularly for a
li
po somal formula consisting of the sphingomyelin As a
result, it was found that its barrier (occlu ive) ability
against water eva
po ration was superior to that oflecithin as
a representative glycerophospholipid, due to a higher
rigidity in the bilayer membrane of the li
po some.
Therefore, it is expected that sphingomyelin will show a
complementary effect for damaged intercellular lipid
structures of the stratum corneum when it is applied to skin
care products. In addition, it was demonstrated that a skin
care product with sphingomyelin had a high
moisturizing/emollient ability and an improvement effect
on existing wrinkles.
SEIWA KASEI Co., Ltd., 1-2-14, Nunoichi-cho, Trend on Alternative to Animal Testing
Higashiosaka 579-8004, Japan
Hajime Kojima
Hydrolyzed proteins and silicones have been widely used
and played an important role in hair treatment. Effects on Japanese Center for the Validation of Alternative Methods
hair, of a newly developed hybrid
po lymer consisting of (JaCVAM), Division of Pharmacology, Biological Safety
hydrolyzed protein, alkyl chain and silicone was Research Center, National Institute of Health Sciences 1-
investigated. It was clear that the polymer was effective in 18-1, Kamiyouga, Setagaya-ku, Tokyo 158-8501, Japan
preventing dyed hair from discoloring and in i
mp roving the
moisture feel of hair. It was confirmed that the
po lymer had
good substantivity contributing to hair luster,
manageability, moisture feel, smoothness and good
combability. The above effects were remarkably displayed
especially on damaged hair. Furthermore, a sensory test in
practical use of shampoo even with the polymer highly
diluted supported the above results.
For the promotion of 3R's (Reduction, Refinement,
Replacement) principles of animal tests, the EU and US
established the European Center for the Validation of
Alternative Methods (ECVAM) and the Interagency
Coordinating Committee on the Validation of Alternative
Methods (ICCVAM), respectively. The purpose of these
centers is to detect reliability and relevance of alternative
methods, which should be determined by intra- and inter-
laboratory validation and peer review for their regulatory
Stabilization and Application of Li
po somal Structures acceptance. A similar institute was established in Japan, the
Containing Sphingomyelin Japanese Center for the Validation of Alternative Methods
(JaCVAM) in the National Institute of Health Sciences
Chihiro Kaise, Teruhisa Kaneko (NIHS). However, there are not enough resources in Japan.
It is necessary to cooperate with a Japanese science society
R&D Control Department, SHU UEMURA Inc., 5-7-17, like the Japanese Society of Alternatives to Animal
Minami Aoyama, Minato-ku, Tokyo 107-0062, Japan Experiments (JSAAE) and a Japanese industry group like
the Japanese Cosmetic Industry Association (JCIA). We are
Cosmetic products with high affinity to the skin have been expecting JaCVAM to contribute to the validation and peer
recently studied, applying liposome and nano-sized review of new alternative methods with supporters and
capsules formed by amphiphiles such as lecithin and other international cooperation for the evaluation of the safety of
lipids to them. Sphingolipid, based on the sphingosine cosmetic ingredients and products.
