JOURNAL OF COSMETIC SCIENCE 342 (137) A. Santini, S. M. Cammarata, G. Capone, A. Ianaro, G. C. Tenore, L. Pani, and E. Novellino, Nutra- ceuticals: opening the debate for a regulatory framework, Br. J. Clin. Pharmacol., 84, 659–672 (2018). (138) Amazon Inc., Collagen Moisture Filler/Combleur Hydrant, Amazon Inc., Seattle, WA, USA (https:// www.amazon.com/Moisturizer-LOreal-Paris-Anti-Aging-Lightweight/dp/B002JDUMFO) (139) Gold Collagen Minerva Research Labs, Pure Gold Collagen, Minerva Research Labs, New Bond St. London, W1S 1DN, UK, (https://www.gold-collagen.com/us/pure-gold-collagen-mini) (140) Amazon Inc., Medicube Triple Collagen Essential Serum, Amazon Inc., Seattle, WA, USA (https:// www.amazon.com/Medicube-Triple-Collagen-Essential-Essence140ml/dp/B07B2SZC5M) (141) N. Shokri, H. Akbari Javar, and R. Ghadermazi, Effects of skin penetration enhancers in topical antiaging products containing α-HydroxyAcids and hyaluronic acid, Avicenna J. Med. Biochem., 2, 2 (2014). (142) W . Sun, M. Inayathullah, M. A. C. Manoukian, A. V. Malkovskiy, S. Manickam, M. P. Marinkovich, A. T. Lane, L. Tayebi, A. M. Seifalian, and J. Rajadas, Transdermal delivery of functional collagen via polyvinylpyrrolidone microneedles, Ann. Biomed. Eng., 43, 2978–2990 (2015). (143) E . B. Souto, R. H. Muller, and S. Gohla, A novel approach based on lipid nanoparticles (SLN) for topical delivery of alpha-lipoic acid, J. Microencapsul., 22, 581–592 (2005).

Supplementary table I Current approaches for topical skin Anti-aging formulations Title Formulation type Drug Evaluation Refs. Formulation and evaluation of curcumin gel for topical application Conventional (gel) Curcumin Viscosity measurement was determined by using a Brookfi eld viscometer (70) Franz diffusion cells was used for in vitro skin permeation study Visual assessment of skin irritation in Wistar albino rats was performed by using visual scoring scale Evaluation of the anti-infl ammatory effect of the optimized formulations was detected by using carrageenan-induced rat paw edema method Preparation and evaluation of submicron carriers for NGN topical application Submicron emulsion Naringenin Viscosity measurement was determined by a cone-and-plate rheometer (92) Measurement of the droplet size was measured by the DLSa technique In vitro skin permeation studies were conducted via Franz diffusion cells Drug deposition in SCb, epidermis, and dermis was determined via HPLCcafter layer separations: (the SC was removed using an adhesive tape, and theepidermis was separated from the dermis by heat) Histological evaluation of skin irritation in male Sprague–Dawley rats was performed. Physical, chemical, and thermodynamic short-term stability studies had been conducted SKIN-AGING AND INFLAMMAGING TREATMENT 343