333 Topical Apple Derivatives
photooxidative damage, and warrant further study. With the extensive marketing
touting the benefits of apple derivatives to consumers, this systematic review extensively
searched and condensed the effects of apple derivatives to inform medical professionals
and the public of the current evidence for its use in cosmetic or pharmaceutical science.
Further research into the compounds in these derivatives can elucidate mechanisms of
use found in apples, a cheap and commonly used fruit that has been used for skincare
for centuries.
REFERENCES
(1) La L, Rh F, YG, MW, SG, Al K, Dc P, Bj Z, Ja W, and Sl Z. Apple cider vinegar soaks do not alter the
skin bacterial microbiome in atopic dermatitis. PLOS ONE. 2021 16(6).
(2) Patocka J, Bhardwaj K, Klimova B, et al. Malus domestica: a review on Nutritional Features, Chemical
Composition, Traditional and Medicinal Value. Plants (Basel). 2020 9(11):1408. doi:10.3390/plants9111408
(3) Acquavia MA, Pascale R, Foti L, et al. Analytical methods for extraction and identification of primary and
secondary metabolites of apple (Malus domestica) fruits: a review. Separations. 2021 8(7):91. doi:10.3390/
separations8070091
(4) Badolati N, Sommella E, Riccio G, et al. Annurca apple polyphenols ignite keratin production in
hair follicles by inhibiting the pentose phosphate pathway and amino acid oxidation. Nutrients.
2018 10(10):1406. doi:10.3390/nu10101406
(5) AK, TT, and YW. Investigation of topical application of procyanidin B-2 from apple to identify its
potential use as a hair growing agent. Phytomed Int J Phytother Phytopharmacol. 2000 7(6).
(6) GR, ES, NB, ES, SB, PC, MD, Gc T, MS, and EN. Annurca apple polyphenols protect murine hair
follicles from taxane induced dystrophy and hijacks polyunsaturated fatty acid metabolism toward
β-oxidation. Nutrients. 2018 10(11).
(7) Malus Fruit P. Extract (explained +products). https://incidecoder.com/ingredients/pyrus-malus-fruit-
extract. Accessed 12/6/2023.
(8) Goodal Apple AHA. Clearing Ampoule 30ml |Korean moisturizer. StyleKorean.com. http://stylekorean.
com/shop/goodal-apple-aha-clearing-ampoule-30ml/1587958891/. Accessed 12/6/2023.
(9) Medix. 10% glycolic +lactic acid overnight exfoliating face peel face serum. Medix55.com. https://
medix55.com/products/medix-5-5-10-glycolic-lactic-acid-overnight-exfoliating-face-peel-face-serum.
Accessed 12/6/2023:5.5.
(10) Antioxidant moisturizer. Juice beauty. https://juicebeauty.com/products/antioxidant-moisturizer. Accessed
12/6/2023.
(11) ASEAN cosmeceuticals market size and growth [report]. https://www.fortunebusinessinsights.com/
asean-cosmeceuticals-market-106253. Fortune Business Insights vol 2028.
(12) Hm SK, B AK, Q AJ, F UK, and NA. Silicone based water-in-oil emulsion fortified with anthocyanin:
in-vitro, in-vivo study. Pak J Pharm Sci. 2021 34(3).
(13) Stojiljković D, Nešić I, Tadić V, Najman S, Stojanović SSS, Standardized wild apple fruit extract as a
bioactive agent in dermocosmetic products for efficacy skin hydration-in vitro and in vivo evaluation.
J Cosmet Dermatol. 2022 21(10):4788–4795. doi:10.1111/jocd.14787
(14) Goretsky MJ, Supp AP, Greenhalgh DG, Warden GD, and Boyce ST. Surface electrical capacitance as
an index of epidermal barrier properties of composite skin substitutes and skin autografts. Wound Repair
Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc. 1995 3(4):419–25.
(15) T, AK, YY, SH, and YW. The first clinical trial of topical application of procyanidin B-2 to investigate
its potential as a hair growing agent. Phytother Res PTR. 2001 15(4).
(16) T, AK, MK, MT, and MM. Investigation of the topical application of procyanidin oligomers from apples
to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005 4(4).
photooxidative damage, and warrant further study. With the extensive marketing
touting the benefits of apple derivatives to consumers, this systematic review extensively
searched and condensed the effects of apple derivatives to inform medical professionals
and the public of the current evidence for its use in cosmetic or pharmaceutical science.
Further research into the compounds in these derivatives can elucidate mechanisms of
use found in apples, a cheap and commonly used fruit that has been used for skincare
for centuries.
REFERENCES
(1) La L, Rh F, YG, MW, SG, Al K, Dc P, Bj Z, Ja W, and Sl Z. Apple cider vinegar soaks do not alter the
skin bacterial microbiome in atopic dermatitis. PLOS ONE. 2021 16(6).
(2) Patocka J, Bhardwaj K, Klimova B, et al. Malus domestica: a review on Nutritional Features, Chemical
Composition, Traditional and Medicinal Value. Plants (Basel). 2020 9(11):1408. doi:10.3390/plants9111408
(3) Acquavia MA, Pascale R, Foti L, et al. Analytical methods for extraction and identification of primary and
secondary metabolites of apple (Malus domestica) fruits: a review. Separations. 2021 8(7):91. doi:10.3390/
separations8070091
(4) Badolati N, Sommella E, Riccio G, et al. Annurca apple polyphenols ignite keratin production in
hair follicles by inhibiting the pentose phosphate pathway and amino acid oxidation. Nutrients.
2018 10(10):1406. doi:10.3390/nu10101406
(5) AK, TT, and YW. Investigation of topical application of procyanidin B-2 from apple to identify its
potential use as a hair growing agent. Phytomed Int J Phytother Phytopharmacol. 2000 7(6).
(6) GR, ES, NB, ES, SB, PC, MD, Gc T, MS, and EN. Annurca apple polyphenols protect murine hair
follicles from taxane induced dystrophy and hijacks polyunsaturated fatty acid metabolism toward
β-oxidation. Nutrients. 2018 10(11).
(7) Malus Fruit P. Extract (explained +products). https://incidecoder.com/ingredients/pyrus-malus-fruit-
extract. Accessed 12/6/2023.
(8) Goodal Apple AHA. Clearing Ampoule 30ml |Korean moisturizer. StyleKorean.com. http://stylekorean.
com/shop/goodal-apple-aha-clearing-ampoule-30ml/1587958891/. Accessed 12/6/2023.
(9) Medix. 10% glycolic +lactic acid overnight exfoliating face peel face serum. Medix55.com. https://
medix55.com/products/medix-5-5-10-glycolic-lactic-acid-overnight-exfoliating-face-peel-face-serum.
Accessed 12/6/2023:5.5.
(10) Antioxidant moisturizer. Juice beauty. https://juicebeauty.com/products/antioxidant-moisturizer. Accessed
12/6/2023.
(11) ASEAN cosmeceuticals market size and growth [report]. https://www.fortunebusinessinsights.com/
asean-cosmeceuticals-market-106253. Fortune Business Insights vol 2028.
(12) Hm SK, B AK, Q AJ, F UK, and NA. Silicone based water-in-oil emulsion fortified with anthocyanin:
in-vitro, in-vivo study. Pak J Pharm Sci. 2021 34(3).
(13) Stojiljković D, Nešić I, Tadić V, Najman S, Stojanović SSS, Standardized wild apple fruit extract as a
bioactive agent in dermocosmetic products for efficacy skin hydration-in vitro and in vivo evaluation.
J Cosmet Dermatol. 2022 21(10):4788–4795. doi:10.1111/jocd.14787
(14) Goretsky MJ, Supp AP, Greenhalgh DG, Warden GD, and Boyce ST. Surface electrical capacitance as
an index of epidermal barrier properties of composite skin substitutes and skin autografts. Wound Repair
Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc. 1995 3(4):419–25.
(15) T, AK, YY, SH, and YW. The first clinical trial of topical application of procyanidin B-2 to investigate
its potential as a hair growing agent. Phytother Res PTR. 2001 15(4).
(16) T, AK, MK, MT, and MM. Investigation of the topical application of procyanidin oligomers from apples
to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005 4(4).
