358 JOURNAL OF COSMETIC SCIENCE
ACKNOWLEDGMENTS
The authors are thankful to Aarti Drugs Ltd., India, for providing a gift sample of
ketoconazole.
REFERENCES
(1) Amra K, Momin M. Formulation evaluation of ketoconazole microemulsion-loaded hydrogel with
nigella oil as a penetration enhancer. J Cosmet Dermatol. 2019 18(6):1742-1750. doi:10.1111/jocd.12945
(2) Solmi M, Radua J, Olivola M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis
of 192 epidemiological studies. Mol Psychiatry. 2022 27(1):281-295. doi:10.1038/s41380-021-01161-7
(3) Heath CR, Usatine RP. Seborrheic dermatitis. J Fam Pract. 2021 70(9):E3-E4. doi:10.12788/jfp.0315
(4) Leurox JC, Vintiloiu A. Organogels and their use in drug delivery – a review. J Control Release.
2008 25:179-192.
(5) Schroeter A, Engelbrecht T, Neubert RHH, Goebel ASB. New nanosized technologies for dermal and
transdermal drug delivery. A review [a review]. J Biomed Nanotechnol. 2010 6(5):511-528. doi:10.1166/
jbn.2010.1149
(6) Nastiti CMRR, Ponto T, Abd E, Grice JE, Benson HAE, Roberts MS. Topical Nano and microemulsions
for skin delivery. Pharmaceutics. 2017 9(4). doi:10.3390/pharmaceutics9040037
(7) Das S, Lee SH, Chow PS, Macbeath C. Microemulsion composed of combination of skin beneficial oils as
vehicle: development of resveratrol-loaded microemulsion based formulations for skin care applications.
Colloids Surf B Biointerfaces. 2020 194:111161. doi:10.1016/j.colsurfb.2020.111161
(8) Garg A, Sharma GS, Goyal AK, Ghosh G, Si SC, Rath G. Recent advances in topical carriers of anti-
fungal agents. Heliyon. 2020 6(8):e04663. doi:10.1016/j.heliyon.2020.e04663
(9) Choukse R, Patel R, Sonawane A, Tripathi H. Formulation and evolution of ketoconazole hydrogel gel
topical delivery system against fungal infection. Int J Pharm Life Sci. 2021 12:74-88.
(10) Kumari KMU, Yadav NP, Luqman S. Promising essential oils/plant extracts in the prevention and
treatment of dandruff pathogenesis. Curr Top Med Chem. 2022 22(13):1104-1133. doi:10.2174/156802662
2666220531120226
(11) Clark M, Finkel R. Pharmacology in Baltimore. 4th ed. Lippincott Williams &Wilkins 2009:411.
(12) Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and
other medicinal properties. Clin Microbiol Rev. 2006 19(1):50-62. doi:10.1128/CMR.19.1.50-62.2006
(13) Wróblewska M, Szymańska E, Winnicka K. The Influence of Tea Tree Oil on Antifungal Activity and
Pharmaceutical Characteristics of Pluronic® F-127 Gel Formulations with Ketoconazole. Int J Mol Sci.
2021 22(21). doi:10.3390/ijms222111326.
(14) Deore SK, Surawase RK, Maru A. Formulation and evaluation of o/w nanoemulsion of ketoconazole. Res
J Pharm Dosage Forms Technol. 2019 11(4):269. doi:10.5958/0975-4377.2019.00045.4
(15) van Staden D, du Plessis J, Viljoen J. Development of a self-emulsifying drug delivery system for optimized
topical delivery of clofazimine. Pharmaceutics. 2020 12(6):523. doi:10.3390/pharmaceutics12060523
(16) Wang W, Wang M, Zhang J, Liu H, Pan H. Cloud point thermodynamics of paclitaxel-loaded
microemulsion in the presence of glucose and NaCl. Colloids and Surfaces A: Physicochemical and Engineering
Aspects. 2016 507:76-82. doi:10.1016/j.colsurfa.2016.07.086
(17) Mukherjee P, Padhan SK, Dash S, Patel S, Mohapatra PK, Mishra BK. Effect of temperature on
pseudoternary system Tween-80-butanol-hexane-water. J Colloid Interface Sci. 2011 355(1):157-163.
doi:10.1016/j.jcis.2010.12.021
(18) Sabale V, Vora S. Formulation and evaluation of microemulsion-based hydrogel for topical delivery. Int J
Pharm Investig. 2012 2(3):140-149. doi:10.4103/2230-973X.104397
(19) Parakh DR. Development and characterization of ketoconazole loaded organogel for topical drug
delivery. Inventi Rapid NDDS. 2015.
ACKNOWLEDGMENTS
The authors are thankful to Aarti Drugs Ltd., India, for providing a gift sample of
ketoconazole.
REFERENCES
(1) Amra K, Momin M. Formulation evaluation of ketoconazole microemulsion-loaded hydrogel with
nigella oil as a penetration enhancer. J Cosmet Dermatol. 2019 18(6):1742-1750. doi:10.1111/jocd.12945
(2) Solmi M, Radua J, Olivola M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis
of 192 epidemiological studies. Mol Psychiatry. 2022 27(1):281-295. doi:10.1038/s41380-021-01161-7
(3) Heath CR, Usatine RP. Seborrheic dermatitis. J Fam Pract. 2021 70(9):E3-E4. doi:10.12788/jfp.0315
(4) Leurox JC, Vintiloiu A. Organogels and their use in drug delivery – a review. J Control Release.
2008 25:179-192.
(5) Schroeter A, Engelbrecht T, Neubert RHH, Goebel ASB. New nanosized technologies for dermal and
transdermal drug delivery. A review [a review]. J Biomed Nanotechnol. 2010 6(5):511-528. doi:10.1166/
jbn.2010.1149
(6) Nastiti CMRR, Ponto T, Abd E, Grice JE, Benson HAE, Roberts MS. Topical Nano and microemulsions
for skin delivery. Pharmaceutics. 2017 9(4). doi:10.3390/pharmaceutics9040037
(7) Das S, Lee SH, Chow PS, Macbeath C. Microemulsion composed of combination of skin beneficial oils as
vehicle: development of resveratrol-loaded microemulsion based formulations for skin care applications.
Colloids Surf B Biointerfaces. 2020 194:111161. doi:10.1016/j.colsurfb.2020.111161
(8) Garg A, Sharma GS, Goyal AK, Ghosh G, Si SC, Rath G. Recent advances in topical carriers of anti-
fungal agents. Heliyon. 2020 6(8):e04663. doi:10.1016/j.heliyon.2020.e04663
(9) Choukse R, Patel R, Sonawane A, Tripathi H. Formulation and evolution of ketoconazole hydrogel gel
topical delivery system against fungal infection. Int J Pharm Life Sci. 2021 12:74-88.
(10) Kumari KMU, Yadav NP, Luqman S. Promising essential oils/plant extracts in the prevention and
treatment of dandruff pathogenesis. Curr Top Med Chem. 2022 22(13):1104-1133. doi:10.2174/156802662
2666220531120226
(11) Clark M, Finkel R. Pharmacology in Baltimore. 4th ed. Lippincott Williams &Wilkins 2009:411.
(12) Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and
other medicinal properties. Clin Microbiol Rev. 2006 19(1):50-62. doi:10.1128/CMR.19.1.50-62.2006
(13) Wróblewska M, Szymańska E, Winnicka K. The Influence of Tea Tree Oil on Antifungal Activity and
Pharmaceutical Characteristics of Pluronic® F-127 Gel Formulations with Ketoconazole. Int J Mol Sci.
2021 22(21). doi:10.3390/ijms222111326.
(14) Deore SK, Surawase RK, Maru A. Formulation and evaluation of o/w nanoemulsion of ketoconazole. Res
J Pharm Dosage Forms Technol. 2019 11(4):269. doi:10.5958/0975-4377.2019.00045.4
(15) van Staden D, du Plessis J, Viljoen J. Development of a self-emulsifying drug delivery system for optimized
topical delivery of clofazimine. Pharmaceutics. 2020 12(6):523. doi:10.3390/pharmaceutics12060523
(16) Wang W, Wang M, Zhang J, Liu H, Pan H. Cloud point thermodynamics of paclitaxel-loaded
microemulsion in the presence of glucose and NaCl. Colloids and Surfaces A: Physicochemical and Engineering
Aspects. 2016 507:76-82. doi:10.1016/j.colsurfa.2016.07.086
(17) Mukherjee P, Padhan SK, Dash S, Patel S, Mohapatra PK, Mishra BK. Effect of temperature on
pseudoternary system Tween-80-butanol-hexane-water. J Colloid Interface Sci. 2011 355(1):157-163.
doi:10.1016/j.jcis.2010.12.021
(18) Sabale V, Vora S. Formulation and evaluation of microemulsion-based hydrogel for topical delivery. Int J
Pharm Investig. 2012 2(3):140-149. doi:10.4103/2230-973X.104397
(19) Parakh DR. Development and characterization of ketoconazole loaded organogel for topical drug
delivery. Inventi Rapid NDDS. 2015.






































































