288 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS *:':' Z..•"•-,* '. • *•- '•** •1, .... •.• • • • ' : . .•- -• .•g • • • ...• -..... • .. .. • .. . . ... -2: .• ' • • ' ••:'•"• • ' • "•"'•.• . ß .-fl.- .• • • - : •,. . .- . - .. . ..... ..?t t • ... -•... '•. . •"• • .. •', --, • : .. •: .... • .... :: -., . ' ,.• .:' .:- ,. ' ':", "c*•' :*-':?": ..... •'"'". ':" -' "' .. :• ...•,, - •, . . . .... . , • -... ::• •...... •......_ ... •%-• • • • ß •. •---.•, .• .•- :• • •::-• . •: •.• :•. : . ....• ..•.•' . • ..... •. - . •. .. .: ., •.:-* r .. ,•..•,-• .•., :½ '•• .... : . .• .-... ' * :-- *• • ,.•"* ..•' ' -• t * .• •-% * -.* -•- •::-. •. -'• .... . -. _.. • .. •._ ß . • . •, ß %. .."• Figure 1.•Section of skin of a testosterone treated male rabbit. Note m•ked hype•lasia of the sebaceous glands and the reduced activity of the hair papillae. .•. 'Z:' '..:• • ,: :,-•:d. : :' -" '"' - Figure 2.--(A) Non-castrated, control rabbit showing poor growth of hair three weeks after clipping. (B) Male castrated rabbit treated with testosterone showing scanty growth of hair. (C) Male castrated rabbit treated with alpha-estradiol showing profuse growth of hair on both sides of abdominal wall.

SYSTEMIC EFFECT OF TOPICALLY APPLIED COSMETICS ß 289 Ef[ect of Application• of I-Iot, rnonem •50C •00C 5O0 1 2 $ 1 • 5 • 5 6 7 1 • 5 ß 5 6 7 $ week inter, val• Figure 3.--The increase weight of hair after estradiol treatment, and the decrease of the weight after testosterone therapy is evident in all three groups. The reversibility o f this phenomenon is obvious after changing from estradiol to testosterone and vice versa. an adrenal disfunction, we saw su•cient histological evidence on eight animals, which indicated a functional disorganization. The most re- markable changes consisted in the derangement of the fascicular zone (Fig. 5), increased mirotic activity in the inter]ocking zone, especial]y ' . ..:•.. -'L•e.'.• •"•. '" ' . •"• ' ". '• t•.:•:::.•':'•.. -" --' '• '•'-'" •:' ' •-'•.:' "%• '•- "•.- ' ':• .... i- .• •:•'- -•, ' •,x. r.•'"-'% •5 ..' • '4½.-z.. '- •'¾ . •.: . -- "2:7..•': ' . .• : • . • • •-• - .'•' • .... " -•. • .... •' • ß •-• . • .... ' :: ..... .•, • .. • •-• .. ,0'-• ,?•, .--.a :,•-%•__ :-, -• :...•-. •, ....... • .,• ... .•, ._. ,_ ,.• .• ,•.• ..... . • • *•, '{½-•'.•. ., ,.:-• - .. .. .... • .. _ • ,. • '• . • • .• ,. . • • •. , • •., ,.• • .-, •'*'E• '•- .. . •.. •.%•[,• •'• - .. . ,'. . .• .,***- ...- , . - :: ,., --. :• .. •.• =..•.- **•. : -. . ... •'.*• : . r. ""'- ' '" Figure 4.--Section of the skin of a castrated male rabbit. Note the reduced size of sebaceous glands and the several active hair follicles.