772 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS PRINCIPLES AND PROCEDURES FOR EVALUATING THE TOXICITY OF HOUSEHOLD SUBSTANCES, prepared by the Committee on Toxicology, Division of Chemistry and Chemical Technology, National Academy of Sciences--National Research Coun- cil. Publication 1138. National Academy of Sciences, Washington, D.C. 1964. 29pages. Price $1.50. This booklet is an attempt by the Committee on Toxicology of the National Academy of Sciences, chaired by A. J. Lehman, to standardize and to forrealize some of the principles and procedures necessary in the evaluation of the toxicity of household substances. Although the booklet is concerned primarily with the requirements of the regulations laid down in the Federal Hazardous Substances La- beling Act of July 12, 1960, its contents are, to a large extent, applicable to cosmetics. It is also likely that future legislation and F.D.A. activity may be influenced by the work of the Committee on Toxicology which prepared this booklet. With regard to testing proce- dures applicable to cosmetics, sev- eral points are particularly note- worthy: No mention is made of the "standard" Draize rabbit eye test, which employs three rabbits un- rinsed, three rabbits rinsed after two seconds and three rabbits rinsed after four seconds. Instead, the booklet includes only a discus- sion of the modified test, which utilizes six rabbits unrinsed. It is surprising that no recommen- dations are made to improve the notoriously inaccurate instillation and scoring procedures of this test. Nor is an attempt made to suggest use of a "standard" eye irritant by various laboratories to arrive at some semblance of reproducibility from laboratory to laboratory. For the prediction of sensift- zation reactions •n man, guinea pig tests by intradermal injection are recommended because they have been found useful in uncovering substances "capable of producin,g, allergic skin sensitization in man. Human patch testing is recom- mended only if the results of the guinea p•g tests are negative. Whether the procedures described in this little volume are sound or not matters little. They are scientif- ically and officially accepted tech- niques and are part of the law. Despite its high cost (5• per page) this booklet is important to for- mulators, toxicologists and clini- cians who deal with products which may accidentally or deliberately come in contact with the human body.--M. M. R•EGER, Warner- Lambert Pharmaceutical Co.

AUTHOR INDEX TO VOLUME XV Anonymous, Preliminary notes on the deter- mination of anionic sulfates, 33 Anonymous, Report on the present position regarding the toxicology of hair sprays, 45 Austrian, J. A., Van Bommel, C., and Schwartz, N., Influence of color in the en- vironment on perceived fragrance qualities, 465 Babayan, ¾. K., Kaufman, T. G., Lehman, H., and Tkaczuk, R. J., Some uses and applications of polyglycerol esters in cos- metics and pharmaceutical preparations, 473 Barrels, P. H., Quantitative microscopy in the cosmetic industry, 485 Battlsta, G. W., see Rieger, M. M. Berth, P., and Reese, G., Modification of hair keratin by cosmetic treatment and natural influences, 659 Bertrand, .[., see Kalopissis, G. Brett, L. C. J., The duty of care and its im- plications, 195 Bromley, J. M., Modern trends in the assess- ment of shampoos, 631 Brown, A. E., Dr. Anthony M. Schwartz, The scientist and the man, 67 Bryant, A., see Kalopissis, G. Buckley, W. R., and Grum, F., The measure- ment of skin color, spectrophotometric technique, 79 Butcher, E. O., The effects of thallium and hair growth in the rat, 129 Carson, S., and Oser, B. L., Dermal toxicity of sodium lauryl sulfate, 137 Catacalos, G., see Wood, J. H. Curby, W. A., An evaluation of the contribu- tion of lung air to total oral odor, 541 Curby, W. A., and Elsanti, V. F., Methods for evaluation of products designed for oral odor control, 285 Daniels, F. Jr., Some comments and sugges- tions for the measurement of protective effect of sunscreens, 709 deNavarre, M. G., Origins of the I.F.S.C.C., 525 Desai, S. J., see Kanig, J. L. Ebllng, E. J., The activity of the hair follicle, 447 Facq, J., Kirk, D. L., and Rebell, G., A simple replica technique for the observa- tion of human skin, 87 Felletschin, G., Properties and uses of newer synthetic detergent raw materials, 245 Fitzpatrick, T. B., Some aspects of melanin pigmentation, 297 Freytag, H., Investigation of permanent waving of human hair, 667 Freytag, H., pH changes of aqueous solutions caused by contact with skin, 265 Gaunt, I. F., and Harper, K. H., The poten- tial irritancy to the rabbit eye mucosa o • certain commercially available shampoos, 209 Giles, W. H., see Wood, J. H. Goff, S., and Levenstein, I., Measuring the effects of topical preparations upon the healing of skin wounds, 509 Golberg, L., The assessment of safety in use: Just how much is contributed by feeding studies in animals ? 177 Grum, F., see Buckley, W. R. Gump, W. S., and Walter, G. R., Chemical structure and antlmlcrobial activity of bis- phenols. IV. Broad spectrum evalua- tion of 2,2'-methylenebis (Dichloro- phenols), 717 Harper, K. H., see Gaunt, I. F. Herzberg, J. J., Action on skin of the tensldes in bath additives, 233 Holmes, A. W., Diffusion processes in human hair, 595 Jass, H. E., see Wooding, W. M. Kalopissis, G., Bryant, A., and Bertrand, J., Synthesis and use in hair preparations of some new quaternary dyes derived from anthr aquinone, 411 Kanig, J. L., and Desai, S. J., The physical- chemical properties of surface-active agents in liquefied halocarbon aerosol systems, 549 Katz, S. A., Turse, R., and Mecca, S. B., Determination of allantoin and the alumi- num allantoinates in various cosmetic and pharmaceutical preparations, 303 Kaufman, T. G., see Babayan, ¾. K. Kinkel, H. J., Inhalation and toxicity studies, 395 Kinmont, P. D.C., Skin reactions to cosmetic preparations, 3 Kirk, D. L., see Facq, J. Kligman, A.M., Howard Mercer, Ph.D., 534 Klinkhamer, J. M., and Lisanti, V. F., Leukocyte damage by oral products, 149 Kramer, R. A., A review of activities, 530 Kramer, R. A., Greetings from the president ofU. S.S. C. C., 524 Lawson, D. F., Photomicrography and the photomicrographer, 656 773