COOLING EFFECT OF COLD CREAMS Table V Modifications of Cold Cream USP XVIII- 357 Preparation No. Variation in Formula (in % of Quantity in USP XVIII Formula) Maximum Cooling Effect Atms• in vitro 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 lOO lOO lOO lOO lOO 75 75 5O 5O 5O 5O 25 12.5 6.25 B/75 S B/50 S B/25 S B/12.5 S B/6.25 S B/100 S B/75 S 75 B/50 S 75 B/25 S 75 B/12.5 S 75 B/6.25 S 50 B/100 S 50 B/75 S B/50 S B/25 S B/12.5 S B/6.25 S B/100 S B/100 S B/100 S 5.58 6.20 5.83 5 55 5 97 09 26 2 1 30 36 3 05 41 2.2 2.5 3.2 2.85 3.5 0.7 1.4 0.4 indicates sodium borate S indicates spermaceti. 0 I0 20 30 40 50 60 M•nutes Figure 6. Cooling curves in vitro of modified cold cream USP XVIII

358 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS aration with respect to cooling property, and others exist which are su- perior. The results obtained by altering the formula, although by no means showing a significant increase of cooling action, nevertheless show that with adequate scale experimentation the USP formula could be mod- ified to give good cooling action. (Received October 21, 1971) REFERENCES (1) Sulzberger, M. B., Wolf, J., and Witten, V. H., Dermatology--Diagnosis and Treatment, Year Book, Chicago, 1961, pp. 571,574-5. (2) Pilsbury, D. M., Shelley, W. B., and Kligman, A.M., Dermatology, Saunders, Philadel- phia, 1957, pp. 890-1,898. (3) Masters, E. J., Cleansing Creams and Lotions, in Sagarin, E., Cosmetics--Science and Technology, Interscience, New York, 1957, pp. 81-2, 84. (4) Barnett, G., Emollient Creams and Lotions, in Sagarin, E., Cosmetics--Science and Tech- nology, Interscience, New York, 1957, pp. 102-9. (5) Ibid., pp. 109-10. (6) Burton, A. C., Physiology of Cutaneous Circulation, Thermoregulatory Functions, in Rothman, S., The Human Integument, American Association for the Advancement of Science, Washington, D.C., 1959, pp. 77-87. (7) USP XVIII, Mack Publishing Co., Easton, Pa., 1970, p. 143. (8) Martin, E., Remington's Pharmaceutical Sciences, Mack, Easton, Pa., 1965, p. 537. (9) Typical Cosmetic Formulations Ilustrating the Use o[ Atlas Sorbitol and Sur[actants, Atlas Powder Co. (Chemical Div.), Wilmington, Del., 1967, p. 25. (10) Ibid., p. 26. (11) A Guide to Cosmetic and Pharmaceutical Formulation with Atlas Products, Atlas Powder Co. (Chemical Div.), Wilmington, Del., 1954, p. 30. (12) Ritschel, W. A., Zur pharmazeutischen Mikrobi•ologie bei der Entwickzung yon Externa am Beispiel des a,a-Dicydopencylessigs•iure--diSthylamino--Sthylester--bromoctylats (Ug 767). Arz.-Forsch., 18, 142 (1968). (13) Typical Cosmetic Formulations Ilustrating the Use oj• Atlas Sorbitol and Surj•actants, Atlas Powder Co. (Chemical Div.), Wilmington, Del., 1967, p. 5. (14) List, P. H., Braun, H., and Varnhold, H., K/ihlsalben und ihre K/ihleffekte, Deut. Apoth. Ztg., 109, 685 (1969). (15) Tronnier, H., f)ber die Wirkungsweise indifferenter Salben und Emulsionsysteme an der Haut in A bh•ingigheit yon ihrer Zusammen-Setzung, Editio Cantor, Aulendorf, West Germany, 1964, p. 91.