590 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS (19) Katz, M., and Shaikh, Z., Percutaneous corticosteroid absorption correlated to partition coefficient, Ibid., 54, 591-4 (1965). (20) Scheuplcin, R. J., Mechanism of percutaneous absorption. I. Routes of penetratioa and the influence ooe solubility, J. Invest. Dermatol., 45, 334-46 (1965). (21) Poulsen, B. J., Young, E., Coquilla, V., and Katz, M., Effect ooe topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester, J. Pbarra. Sci., 57• 928-33 (1968). (22) Coldman, M. F., Poulsen, B. J., and Higuchi, T., Enhancement ooe percutaneous absorp- tion by the use of volatile:nonvolatile systems as vehicles, Ibid., 58, 1098-102 (1969). (23) Moore-Robinson, M., and Christie, G., Vasoconstrictor activity of topical corticosteroids. Methodology and results, Brit. J. Dermatol., 82, Supp. 6, 86-92 (1970). (24) Wagner, J. G., Biopharmacet•tics: Absorption aspects, J. Pharm. Sci., 50, 359-87 (1961). (25) Barrett, C. W., Hadgraft, J. W., Caron, G. A., and Sarkany, I., The effect of particle size and vehicle on the percutaneous absorption ooe fluocinolone acetonide, Brit. J. Dermato!., 77, 576-8 (1965). (26) Haleblian, J., and McCrone, W., Pharmaceutical applications ooe polymorphism, ]. Pharm. Sci., 58, 911-29 (1969). (27) Ostrenga, J., Steinmetz, C., Poulsen, B., and Yett, S., Significance of vehicle composition. II. Prediction ooe optimal vehicle composition, Ibid., 60, 1180-3 (1971). (28) Idson, B., Dry skin and emolliency, I, II, III, Drug Cosmet. Ind., 104, 105, June, p. 44 July, p. 48 Aug. p. 48 (1969). (29) Smeenk, G., and Rijnbeek, A.M., The water-binding properties of the water-soluble substances in the horny layer, Acta Dermato-Venereol., 49, 476-80 (1969). (30) Powers, D. H., and Fox, C., The effect of cosmetic emulsions on the stratum corneum, J. Soc. Cosmet. Chem., 10, 109-16 (1959). (31) Wurster, D. E., Factors Influencing the Design and Formulation of Dermatological Preparations, in Goldstein, S. W., Development of Safer and More Effective Drugs, Amer- ican Pharmaceutical Association, Washington, D.C., 1968, pp. 121-40. (32) Scholtz, J. R., Topical therapy of psoriasis with fluocinolone acetonide, Arch. Dermato!., s4, 191-2 (1961). (33) Kligman, A.M., Topical pharmacology and toxicology of dimethyl sulfoxide, Part I, J. Amer. Med. Ass., 198, 140-8 Part II, Ibid, 151-6 (1965). (34) Schumacher, G. E., Some properties of dimethyl sulfoxide in man, Drug Intel., I, 188-94 (1967). (35) Ostrenga, J. O., Haleblian, J., Poulsen, B., Forroll, B., Mueller, N., and Shastri, S., Ve- hicle design for a new topical steroid, fluocinolide, J. Invest. Dermatol., 56, 392-9 (1971). (36) Katz, M., and Neiman, H. M., U.S. Patent 3,592,930 (|uly 13, 1971). (37) Scholtz, J. R., and Dumas, K. J., Standards for Clinical Evaluation o• Topical Steroids, in XIII Congressus Internationalis Dermatologiae, Munchen, 1967, Springer-Verlag, New York, 1968. (38) Mendelson, C. G., and Bessler, S. A., Clinical efficacy of fluocinonide, a new topical corticoid, Cutis, 8, 557-80 (1971) and Spccial C•mmunication 9, 104 (19-2). (39) Milne, J. A., Clinical sequential trials in dern'a•ology, Brit. J. Dermalol., 82, Supp. 6, 99-•03 (1970). (40) Burdick, K. H., Corticosteroid bioavailability assays, Arch. Dermatol. (Stockholm), Suppl. 67 (1971), Fluocinonide International Symposium, Zurich, May 1971.

Book Reviews COMPREHENSIVE BIOCHEMISTRY, VOL. 26, PART C: EXTRACELLULAR AND Sue- PORTING STRUCTURES (Continued), Edited by Marcel Florkin and Elmer H. Stotz. Elsevier Publishing Co., Amsterdam, Netherlands, 1971. 898 pages, indexed. The volume is characterized by clear and precise writing. The reader, whatever discipline he ascribed to in the natural sciences, can well appreciate the manner in which the materials are presented. The chapters on "Chitinous Struc- tures" and "Resilin" are presented, respectively, by Charles Jeuniaux and S. O. Andersen, in a very compre- hensive style. Less comprehensive, but nevertheless interesting and in- formative, is the manner in which Carl Franzblau writes of "ElaNtin." The information on elaNtin, however, would have been more apropos in Part B of this volume. There, with chapters on other fibrous proteins, it would have made Part B more comprehensive. As it is, one is aware of an interruption between Chapters IX and X and the rest of Part C. Margaret Jope's chapter, "Constit- uents of Brachiopod Shells," and John Eastoe's "Dental Enamel" are 591 a treasure for those seeking to fa- miliarize themselves with these sub- jects. Their presentations are com- plete and for those interested in further detail, the writers give ample references. Unfortunately, the same cannot be said of Rend Defretin's "The Tubes of Polychaete Annelids." In many instances the lack of refer- ences prevents one from further pur- suing a point. Apart from the disadvantages men- tioned, the volume is well worth its acquisition.--AscmL CARRmLo--The Gillette Company Research Institute PROBLEME DER LOKALEN STEROIDBE- HANDLUNG, by Wolfgang Raab. Dr. Alfred Huthig Verlag Gmbh, Heidel- berg. xii q- 151 pages, illustrated. Price DM 19,80. This monograph is an unmistak- able sign of a major difference be- tween cosmetics in Europe and in America. The fact that "Problems of Local Corticosteroid Treatment" should be the title of the first vol- ume of a series of books devoted to cosmetics is a clear indication that there is a much larger interface be- tween dermatological and cosmetic