302 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS DHEA CREAM 1% 1% 0.1% 0.1% 0.O1% 0,1% I' '-'« q, •'%%•".I•i •-' ' .•:• ' • I ! ....... -1 .......... •*'"'• ,'•-? .... ß - lOO E m 80 i- 60 z •_ 40 u.I 20 1983 1984 Figure 9. The effect of topically applied DHEA cream on sebum secretion rate. Each data point represents the mean of all three subjects. Open bar indicate placebo treatments. NADPH (via direct inhibition of glucose-6-phosphate dehydrogenase), DHEA also in- hibits lipogenesis, weight gain, and diabetes in experimental animals (2). Because of its unique background of known beneficial effects and its unique local sebo- trophic action, topical DHEA may prove to be the product of choice for increasing sebum production in post-menopausal women. REFERENCES (1) J. Sonka, Dehydroepiandrosterone•Metabolic Effects (Universita Learlova, Prague, CSSR 1976). (2) A. G. Schwartz, L. L. Pashko, E. E. Henderson, R. I. Tannen, M. P. Cleary, M. Abon-Gharbia, and D. Swern, Dehydroepiandrosterone: An anti-obesity and anticarcinogenic agent, Commentaries on Research in Breast Disease, 3, 113-130 (1983). (3) W. D. Drucker, A.M. Blumberg, H. M. Gandy, R. R. David, and A. L. Verde, Biological activity of dehydroepiandrosterone sulfate, J. Clin. Endocrinol. Metab., 35, 48-54 (1972). (4) N. Orentreich, J. L. Brind, R. L. Rizer, and V. H. Vogelman, Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood, J. Clin. Endo. Metab., 59, 551-555 (1984). (5) P. E. Pochi and J. S. Strauss, "The Effect of Aging on the Activity of the Sebaceous Gland in Man," in Advances in the Biology of Skin, Vol. VI.' Aging, W. Montagna, Ed. (Pergamon Press, New York, 1965). (6) J. S. Strauss, D. T. Downing, and F. J. Ebling, "Sebaceous Glands," in Biochemistry and Physiology of the Skin, L. A. Goldsmith, Ed. (Oxford University Press, Oxford, 1983), pp. 569-595. (7) J. R. Matias and N. Orentreich, The hamster ear sebaceous gland. I. Examination of the regional variation by stripped skin planimetry, J. Invest. Dermatol., 81, 43-46 (1983). (8) N. Orentreich and J. R. Matias, "The Long-Haired Syrian Hamster: An Animal Model for An- drogen-Induced Hair Growth, in Skin Models, R. Marks and G. Piewig, Eds. (Springer-Verlag, Berlin, 1986), pp. 165-171.

STIMULATION OF SEBACEOUS GLANDS 303 (9) (lO) (11) (12) (13) (14) (15) (16) (17) J. R. Matias, V. L. Malloy, and N. Orentreich, A comparative study of the effects of percutaneously administered 5-reductase and androgen receptor inhibitors on hamster sebaceous glands, Ann. NY Acad. Sci., 435, 454-456 (1984). J. S. Strauss and P. E. Pochi, The quantitative gravimetric determination of sebum production, J. Invest. Dermatol., 36, 293-298 (1961). G. Piewig and C. Luderschmidt, Hamster ear model for sebaceous glands, J. Invest. Dermatol., 68, 171-176 (1977). S. Takayasu and K. Adachi, The intranuclear binding of 17B-hydroxy-5ot-androstan-3-one and tes~ rosterone by hamster sebaceous glands, Endocrinol., 96, 525-529 (1975). K. Adachi, Receptor proteins for androgens in hamster sebaceous glands, J. Invest. Dermatol., 62, 217-233 (1974). N. Orentreich, J. R. Matias, and V. Malloy, The local anti-androgenic effect of the intracutaneous injection of progesterone in the flank organ of sexually mature male Syrian golden hamsters. Arch. Dermatol. Res., 276, 401-405 (1984). A. G. Schwartz, Inhibition of spontaneous breast cancer formation in female. C3H-A/A mice by long-term treatment with dehydroepiandrosterone, Cancer Res., 39, 1129-1132 (1979). J. R. Matias, V. L. Malloy, A. Chin, C. P. DeFeo, and N. Orentreich, Effect of dehydroepiandros- terone on the growth rate of transplantable tumors, Third Colloquium in Biological Sciences, NY Acad. Sd. Accepted for publication (1985). J. W. Nyce, P. N. Magee, and A. G. Schwartz, Antipromotion of dimethyl-hydrazine induced mu- rine colonic carcinoma by dehydroepiandrosterone, Ann. NY Acad. Sci., 397, 317-319 (1982).