SURFACTANT-SKIN INTERACTIONS 229 b Figure 5. (a) Occasional presence ofdisjunctum in formulation C-treated tissue (TEWL 11 g/m 2 hr). Outer lipid layers (arrow) were generally featureless (24,000x). (b) Gross intracellular damage (arrowheads) and loss of intercellular lipids (arrows) can be seen in this high-magnification view of formulation C-treated tissue (128,000x).

230 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 6. Swelling of the cells was visible in the formulation C-treated tissue (a). Damage extended to deeper layers of corneocytes. Often up to 4-6 cell layers were damaged in tissue displaying higher TEWL values (a and b). Extensive damage often resulted in the loss of most of the cell layers of the SC (c) such regions were present in tissue displaying high TEWL (-30 g/m 2 hr). (24,000x [a and c], 128,000x [b].)

Purchased for the exclusive use of nofirst nolast (unknown)
From: SCC Media Library & Resource Center (library.scconline.org)