SURFACTANT-SKIN INTERACTIONS 225 Figure 1. (c) Water-washed control tissue showing the presence of interlayer desmosomes (arrowheads) in the outer regions of SC and absence of disjuncture (24,000x). (d) Multilayered lipid lamellae (arrows) enveloping the outer layers of corneocytes and desmosomes (arrowheads) were seen in those regions of control tissue that lacked disjuncture (128,000x).

226 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS - -L Figure 2. (a) Formulation A-treated tissue showing disjunctum--compactum region (24,000x). (b) Well- preserved, multiple layers of lipid lamellae (arrows) in lower layers of SC (128,000x). exhibited significant damage to lipids and proteins in the top 4-6 cell layers of stratum corneum (Figure 6a,b). Often, the entire disjunctum and most of the compacturn ap- peared destroyed (Figure 6c). Damage to the inter- and intracellular regions was quali- tatively similar in all the samples irrespective of individual variations in water loss. However, the extent of damage ranged from the top few layers to the deeper layers,

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