DEGERMING EFFICIENCY OF HEXACHLOROPHENE SOAPS 281 The applications of radioisotopes isotopes in their field. We realize are all new and there is no exaggera- that the results described will not tion in saying that new methods give you enough information on have to be devised every day, so this important subject. We had that practically each type of corn- planned to bring more data, pound is tagged with its own but were unable to do so because choice isotope and has a method of other experiments we are now its own which gives better results running on other types of cosmetics than any other one. The purpose have not been completed yet. Very of this short presentation was to soon we will be in a position to give cosmetic chemists the basic make more valuable data avail- fundamentals on the use of radio- able. A METHOD FOR TESTING THE DEGERMING EFFICIENCY OF HEXACHLOROPHENE SOAPS* By ARTHUR R. CADS, PH.D. Research Laboratories, Sindar Corp., Delawanna, N. •. THE PURPOSE of thispaperis reduction in the numbers of vi- the presentation of a simplified able bacteria present is a desired in vivo method for determining end. Chart 1 shows the struc- the efficacy and relative efficiency tural formula for hexachlorophene. of hexachlorophene in soap as a Although hexachlorophene finds skin-degerming agent. The name many practical applications due hexachlorophene is the generic term to its effective antiseptic and germi- accepted by the Council on Phar- cidal qualities, details as to these macy and Chemistry of the Ameri- uses will be left for other publi- can Medical Association for the cations. We are concerned in this chemical "bis (3, 5, 6-trichloro-2- paper only with the one property, hydroxyphenyl) methane," which namely, the degerming of the skin substance has been shown during and how to determine it. This the past few years to be an excellent process includes three or more germicide and a powerful bacteri- allied or associated processes ostatic agent, thus applicable for namely, those of killing the bacteria extended use in both medical and (germicidal action), preventing their public health fields for condi- growth (antisepsis or bacteriostasis), tions where the removal of or the and the mechanical removal of the bacteria by washing. * Presented at the December 5, 1950, Meeting, New York City. The procedure to be presented

DEGERMING EFFICIENCY OF HEXACHLOROPHENE SOAPS 281 The applications of radioisotopes isotopes in their field. We realize are all new and there is no exaggera- that the results described will not tion in saying that new methods give you enough information on have to be devised every day, so this important subject. We had that practically each type of corn- planned to bring more data, pound is tagged with its own but were unable to do so because choice isotope and has a method of other experiments we are now its own which gives better results running on other types of cosmetics than any other one. The purpose have not been completed yet. Very of this short presentation was to soon we will be in a position to give cosmetic chemists the basic make more valuable data avail- fundamentals on the use of radio- able. A METHOD FOR TESTING THE DEGERMING EFFICIENCY OF HEXACHLOROPHENE SOAPS* By ARTHUR R. CADS, PH.D. Research Laboratories, Sindar Corp., Delawanna, N. •. THE PURPOSE of thispaperis reduction in the numbers of vi- the presentation of a simplified able bacteria present is a desired in vivo method for determining end. Chart 1 shows the struc- the efficacy and relative efficiency tural formula for hexachlorophene. of hexachlorophene in soap as a Although hexachlorophene finds skin-degerming agent. The name many practical applications due hexachlorophene is the generic term to its effective antiseptic and germi- accepted by the Council on Phar- cidal qualities, details as to these macy and Chemistry of the Ameri- uses will be left for other publi- can Medical Association for the cations. We are concerned in this chemical "bis (3, 5, 6-trichloro-2- paper only with the one property, hydroxyphenyl) methane," which namely, the degerming of the skin substance has been shown during and how to determine it. This the past few years to be an excellent process includes three or more germicide and a powerful bacteri- allied or associated processes ostatic agent, thus applicable for namely, those of killing the bacteria extended use in both medical and (germicidal action), preventing their public health fields for condi- growth (antisepsis or bacteriostasis), tions where the removal of or the and the mechanical removal of the bacteria by washing. * Presented at the December 5, 1950, Meeting, New York City. The procedure to be presented