DEQUALINIUM SALTS AND PITYROSPORUM OVALE 37 hydrogen bonds may well prove as important as cleavage of disulphide bonds in investigating load-rotation curves of hair fibres. (Received: 24th November 1958) REFERENCES • Speakman, J. B. Melliand Textilber., 33 (1952) 823. 2 Fuhrmann, W. Melliand Textilber., 33 (1952) 911. a Zahn, H. Textil-t•raxis, 9 (1954) 515. • Richter, R., and Fuhrmann, W. Arch. Dermatol u. Syphilis (D), 198 (1954) 274. 5 Astbury, W. T,, and Woods, H. J. t•hil. Trans. Roy. Soc. London. Ser. zi., 232 (1933) 333, 0 Harrison, W. J. Textile Inst., 28 (1937) 110. ? Pauling, L., Corey, R. B., and Branson, H. R. t•roc. Nat. zicad. Sci. U.S., 37 (1951) 205. s Hirsch, F. Kosmetik-t•arfurn-Drogen Rundschau (1955) (7/8) 81. 9 Hirsch, F. Das Haar des Menschen in Gesundtheit u•d _t•rankheit unler spezieller Ber•icksichtigung der _t•eratinchemie (1956) (Haug-Verlag, Ulm). •0 Hirsch, F. Heilkunst, 65 (1952) 2. • Heiling6tter, R. _t•osrnetik-t•arfurn-Drogen Rundschau (1956) (9/10) 121. •2 Heiling6tter, R. Am. t•erfumer •trornat., 68 (1956) (November) 17. •a Mercer, E.H. Textile Research J., 23 (1953) 388. • Hirsch, F. Angew. Chem., 67 (1955) 715. •5 Hirsch, F. Beitragzurziufkl•rungderKeratinstruktur (1952). Dissertation, Miinchen. •0 Hirsch, F. M•inch. reed. Wochschr., 42 (1951) 2105. •? Hirsch, F. M•inch. reed. Wochschr., 44 (1953) 1175. •8 Hirsch, F. J. Medizinische Kosmetik, (1955) 155. • Crick, F. H.C. Nature, 170 (1952) 882. 20 Pauling, L., and Corey, R. B. Nature, 17! (1953) 59. 2• Pauling, L. zingew. Chem., 67 (1955) 244. 22 Goldworthy, J. E., and Lang, J. J. Textile Inst., Trans. 44 (1953) 230. 23 Huggins, O.O. Proc. Nat. :icad. Sci. U.S., 43 (1957) 204. THE EFFECT OF DECAMETHYLENE-BIS-4- AMINOQUINALDINIUM (DEQUALINIUM) SALTS ON THE GROWTH OF PITYROSPORUM OVALE P. F. D'ARCY, B.PHARM., PH.D., M.P.S. W. A. COX, B.Sc. M. J. HEDGE, B.PHARM., F.P.S., and G. R. WILKINSON, F.P.S.* Dequalinium salts restrict the growth ot Pityrosporum ovate and other micro-organisms contaminating skin and hair. Preparations of Dequalinium are highly effective in the treatment of seborrhoea and intective dandruff. INTRODUCTION ]DANDRUFF IS characterized by the presence of loosely adhering scales on "the scalp the scales are flakes of the stratum corneum or horny layer of the * Research Division, Allen & Hanburys Ltd., Ware, Herts.
DEQUALINIUM SALTS AND PITYROSPORUM OVALE 37 hydrogen bonds may well prove as important as cleavage of disulphide bonds in investigating load-rotation curves of hair fibres. (Received: 24th November 1958) REFERENCES • Speakman, J. B. Melliand Textilber., 33 (1952) 823. 2 Fuhrmann, W. Melliand Textilber., 33 (1952) 911. a Zahn, H. Textil-t•raxis, 9 (1954) 515. • Richter, R., and Fuhrmann, W. Arch. Dermatol u. Syphilis (D), 198 (1954) 274. 5 Astbury, W. T,, and Woods, H. J. t•hil. Trans. Roy. Soc. London. Ser. zi., 232 (1933) 333, 0 Harrison, W. J. Textile Inst., 28 (1937) 110. ? Pauling, L., Corey, R. B., and Branson, H. R. t•roc. Nat. zicad. Sci. U.S., 37 (1951) 205. s Hirsch, F. Kosmetik-t•arfurn-Drogen Rundschau (1955) (7/8) 81. 9 Hirsch, F. Das Haar des Menschen in Gesundtheit u•d _t•rankheit unler spezieller Ber•icksichtigung der _t•eratinchemie (1956) (Haug-Verlag, Ulm). •0 Hirsch, F. Heilkunst, 65 (1952) 2. • Heiling6tter, R. _t•osrnetik-t•arfurn-Drogen Rundschau (1956) (9/10) 121. •2 Heiling6tter, R. Am. t•erfumer •trornat., 68 (1956) (November) 17. •a Mercer, E.H. Textile Research J., 23 (1953) 388. • Hirsch, F. Angew. Chem., 67 (1955) 715. •5 Hirsch, F. Beitragzurziufkl•rungderKeratinstruktur (1952). Dissertation, Miinchen. •0 Hirsch, F. M•inch. reed. Wochschr., 42 (1951) 2105. •? Hirsch, F. M•inch. reed. Wochschr., 44 (1953) 1175. •8 Hirsch, F. J. Medizinische Kosmetik, (1955) 155. • Crick, F. H.C. Nature, 170 (1952) 882. 20 Pauling, L., and Corey, R. B. Nature, 17! (1953) 59. 2• Pauling, L. zingew. Chem., 67 (1955) 244. 22 Goldworthy, J. E., and Lang, J. J. Textile Inst., Trans. 44 (1953) 230. 23 Huggins, O.O. Proc. Nat. :icad. Sci. U.S., 43 (1957) 204. THE EFFECT OF DECAMETHYLENE-BIS-4- AMINOQUINALDINIUM (DEQUALINIUM) SALTS ON THE GROWTH OF PITYROSPORUM OVALE P. F. D'ARCY, B.PHARM., PH.D., M.P.S. W. A. COX, B.Sc. M. J. HEDGE, B.PHARM., F.P.S., and G. R. WILKINSON, F.P.S.* Dequalinium salts restrict the growth ot Pityrosporum ovate and other micro-organisms contaminating skin and hair. Preparations of Dequalinium are highly effective in the treatment of seborrhoea and intective dandruff. INTRODUCTION ]DANDRUFF IS characterized by the presence of loosely adhering scales on "the scalp the scales are flakes of the stratum corneum or horny layer of the * Research Division, Allen & Hanburys Ltd., Ware, Herts.
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