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CHARAKTERISIERUNG VON KOPFSCHUPPEN MITTELS ZELLBIOLOGISCHER PARAMETER Gerh•trd Sauermann*, Renate Hasselmann, Hans-Joachim Kopplow, Ute Heinbockel Synopsis: Ultrasonic disaggregation of dandruff scales into individual epithelial cells and fat droplets was followed with the aid of light scattering photometry. The ratio of the amount of disaggregation at zero time and that after 10 minutes -- as measured by the light scattering index SI -- corre- lates well with a visual classification according to size of scales from 13 test subjects. SI correlates well with the volume of the individual epithelial cells forming the cell clusters, with the lipid content, and presumably also with transepidermal water loss. Transepidermal water loss is consistently correlated with cell volume. PROBLEMSTELLUNG Schuppen stellen ein weitverbreitetes iisthetisches Problem dar, unter dem in der Bundesrepublik viele Millionen Menschen leiden. In ihren schweren Erscheinungs- formen, z. B. der seborrhoeischen Dermatitis' darf von krankhaften Erscheinungen gesprochen werden. Mittels standardisierter Entnahmemethoden gewonnene Epithelzellen dienten in frtiheren Untersuchungen als Proben, um die Intensitiit der StiSrung der Epithelzell- abschilferung und den Normalisierungsverlauf bei Behandlung zu verfolgen. Bei diesera ,,corneocyte-count" genannten Verfahren werden mittels einer wiigrigen, tensidhaltigen LiSsung von einer definierten Oberfliiche mittels standardisierter Ent- nahme-Technik einzelne Epithelzellen und Zellcluster gewonnen, wob•i letztere' unter dem Einflug des Tensids zu einzelnen Ephitelzellen separieren. Die GriSge der Schuppen und ihre morphologischen Charakteristika werden auf diese Weise nicht erfagt. Nun stellt aber nicht nur die Schuppenmenge, sondern auch die Schuppen- griSge eine wichtige EinfluggriSge des Problems ,,Kopfschuppen" dar. Sie kiSnnte mbglicherweise ein Mag fiir die Kopfschuppen bekiimpfende Wirksamkeit yon Haarpfiegeprodukten darstellen. Die Suche nach einer einfachen, praktikablen Me- thode zur Charakterisierung der Schuppengrbge und die Beziehungen dieser GriSge zu anderen Epithelzellpari•metern war das Ziel dieser Arbeit. * Biophysikalisches Met•laboratorium d. Firma Beiersdorf AG, Hamburg 201