BROAD-SPECTRUM SUNSCREENS 149 Figure 8. 16 MPD: Glycosaminoglycans. Mowry's stain (magnification)230). A: SPF-7 sunscreen. Blue-staining GAGs are considerably increased compared to those seen with 10 MPDs. Some collagen bundles have a bluish tone (-•). B: SPF-16 sunscreen. GAGs are as abundant as with the SPF-7 sunscreen.

150 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 8. Continued. C: SPF-18 sunscreen. GAGs are mildly increased, with foci of dense deposits at the dermal-epidermal junction ( •- ). Table I Major Changes With Sunscreen Protectton: 10 MPD vs 16 MPD--Hematoxylin and Eosin Stain Sunscreen group 10 MPD 16 MPD SPF-7 6-8 cell layers Mild loss of order Little or no atypia A few sunburn cells Mild-to-moderate focal inflammation Cysts: 3 rows Granulomatous reaction: severe SPF-16 6-8 cell layers Mild loss of order Little or no atypia A few sunburn cells Mild focal inflammation Cysts: 1-2 rows Granulomatous reaction: mild to severe SPF- 18 5-7 cell layers No loss of order Little or no atypia Sunburn cell rare Very mild focal inflammation Cysts: 1-2 rows Granulomatous reaction: mild 7-9 cell layers: many thick downgrowths Moderate loss of order Severe atypia in downgrowths Many sunburn cells Moderate to severe inflammation Cysts: 3-4 rows Granulomatous reaction: very severe 7-9 cell layers: several thicker downgrowths Mild loss of order Mild atypia in downgrowths Moderate amount of sunburn cells Mild-to-moderate focal inflammation Cysts: 2-4 rows Granulomatous reaction: moderate to severe 6-8 cell layers: very few downgrowths Mild loss of order in downgrowths Little or no atypia A few sunburn cells Mild focal inflammation Cysts: 1-2 rows Granulomatous reaction: mild to focally moderate