THE WHITENING AND ANTI-WRINKLE EFFECT OF PONEGRANATE 159 (24) J. Hosoi, E. Abe, T. Suda, and T. Kuroki, Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid, Cancer Res., 45, 1474–1478 (1985). (25) J. N. Losso, C. N. Munene, R. R. Bansode, and H. A. Bawadi, Inhibition of matrix metalloproteinase-1 activity by the soybean Bowman-Birk inhibitor, Biotechnol. Lett., 26, 901–905 (2004). (26) K. H. Kim, S. J. Park, Y. J. Lee, J. E. Lee, C. H. Song, S. H. Choi, S. K. Ku, and S. J. Kang, Inhibition of UVB-induced skin damage by exopolymers from Aureobasidium pullulans SM-2001 in hairless mice, Basic. Clin. Pharmacol. Toxicol., 116, 73–86 (2015). (27) J. L. Maas, G. J. Galletta, and G. D. Stoner, Ellagic acid, an anticarcinogen in fruits, especially in straw- berries: A review, HortScience, 26, 10–14 (1991). (28) K. C. Thresiamma and R. Kuttan, Inhibition of liver fi brosis by ellagic acid, Indian. J. Physiol. Pharmacol., 40, 363–366 (1996). (29) T. Osawa, A. Ide, J. D. Su, and M. Namiki, Inhibition of in vitro lipid peroxidation by ellagic acid, J. Agric. Food Chem., 35, 808–812 (1987). (30) H. Shimogaki, Y. Tanaka, H. Tamai, and M. Masuda, In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition, Int. J. Cosmet. Sci., 22, 291–303 (2000). (31) J. N. Losso, C. N. Munene, R. R. Bansode, and H. A. Bawadi, Inhibition of matrix metalloproteinase-1 activity by the soybean Bowman–Birk inhibitor, Biotechnol. Lett., 26, 901–905 (2004). (32) N. Maity, N. K. Nema, M. K. Abedy, B. K. Sarkar, and P. K. Mukherjee, Exploring Tagetes erecta Linn fl ower for the elastase, hyaluronidase and MMP-1 inhibitory activity, J. Ethnopharmacol., 137, 1300– 1305 (2011). (33) L. Rittié and G. J. Fisher, UV-light-induced signal cascades and skin aging, Ageing Res. Rev., 1, 705–720 (2002). (3 4) H. D. Kim, H. R. Cho, S. B. Moon, H. D. Shin, K. J. Yang, B. R. Park, H. J. Jang, L. S. Kim, H. S. Lee, and S. K. Ku, Effects of beta-glucan from Aureobasidium pullulans on acute infl ammation in mice, Arch. Pharm. Res., 30, 323–328 (2007). (3 5) K. Kameyama, C. Sakai, S. Kuge, S. Nishiyama, Y. Tomita, S. Ito, K. Wakamatsu, and V. J. Hearing, The Expression of tyrosinase, tyrosinase-related proteins 1 and 2 (TRP1 and TRP2), the silver protein, and a melanogenic inhibitor in human melanoma cells of differing melanogenic activities, Pigment Cell Res., 8, 97–104 (1995). (3 6) Y. Chan, K. Kim, and S. Cheah, Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells, J. Ethnopharmacol., 137, 1183–1188 (2011). (3 7) F. Solano, S. Briganti, M. Picardo, and G. Ghanem, Hypopigmenting agents: An updated review on biological, chemical and clinical aspects, Pigment Cell Res., 19, 550–571 (2006). (3 8) T. Burns, S. Breathnach, N. Cox, and C. Griffi ths, Rook’s Textbook of Dermatology, (John Wiley & Sons, Malden, MA, 2010). (3 9) Y. Xu, Y. Shao, J. J. Voorhees, and G. J. Fisher, Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human kera- tinocytes, J. Biol. Chem., 281, 27389–27397 (2006). (4 0) F. T. Vicentini, Y. M. Fonseca, D. L. Pitol, M. M. Iyomasa, M. V. Bentley, and M. J. Fonseca, Evaluation of protective effect of a water-in-oil microemulsion incorporating quercetin against UVB-induced dam- age in hairless mice skin, J. Pharm. Pharm. Sci., 13, 274–285 (2010). (4 1) L. H. Kligman, The hairless mouse model for photoaging, Clin. Dermatol., 14, 183–195 (1996).