BATTLE AGAINST DANDRUFF 113 (4) R. Hay, Malassezia, dandruff and seborrhoeic dermatitis: An overview, Br. J. Dermatol., 165(S2), 2–8 (2011). (5) Y. M. DeAngelis, C. M. Gemmer, J. R. Kaczvinsky, D. C. Kenneally, J. R. Schwartz, and T. L. Dawson Jr, Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity, J. Investig. Dermatol. Symp. Proc., 10(3), 295–297 (2005). (6) B. I. Ro and T. L. Dawson, The role of sebaceous gland activity and scalp microfl oral metabolism in the etiology of seborrheic dermatitis and dandruff, J. Investig. Dermatol. Symp. Proc., 10(3), 194–197 (2005). (7) G. Gaitanis, A. Velegraki, P. Mayser, and I. D. Bassukas, Skin diseases associated with Malassezia yeasts: Facts and controversies, Clin. Dermatol., 31(4), 455–463 (2013). (8) G. K. Kim, Seborrheic dermatitis and Malassezia species: How are they related? J. Clin. Aesthet. Derma- tol., 2(11), 14–17 (2009). (9) M. Zareei, A. Mohammadi, B. B. Zeinab, and J. H. Seyed, Frequency of different Malassezia species in scalp dandruff. Infect. Epidemiol. Med., 2(2), 22–25 (2016). (10) T. L. Dawson Jr., Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis, J. Investig. Dermatol. Symp. Proc., 12(2), 15–19 (2007). (11) T. Nakatsuji, M. C. Kao, L. Zhang, C. C. Zouboulis, R. L. Gallo, and C. M. Huang, Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expres- sion, J. Invest. Dermatol., 130(4), 985–994 (2010). (12) G. Donnarumma, I. Paoletti, E. Buommino, M. Orlando, M.A. Tufano, and A. Baroni, Malassezia furfur induces the expression of beta-defensin-2 in human keratinocytes in a protein kinase C-dependent manner, Arch. Dermatol. Res., 295(11), 474–481 (2004). (13) A. Baroni, M. Orlando, G. Donnarumma, P. Farro, M. R. Iovene, M. A. Tufano, and E. Buommino, Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur, Arch. Dermatol. Res., 297(7), 280–288 (2006). (14) G. A. Turner, M. Hoptroff, and C. R. Harding, Stratum corneum dysfunction in dandruff, Int. J. Cosmet. Sci., 34(4), 298–306 (2012). (15) R. A. Bacon, H. Mizoguchi, and J. R. Schwartz, Assessing therapeutic effectiveness of scalp treatments for dandruff and seborrheic dermatitis, part 2: The impact of gender and ethnicity on effi cacy, J. Derma- tol. Treat., 25(3), 237–240 (2014).

J. Cosmet. Sci., 68, 114–125 ( January/February 2017) 114 Structure/property comparisons of chemistries based on renewable 1,3-propanediol and petroleum-derived alkylene oxides ERIC LIND, JOHN CHASE, PAT MAYER, JED RIEMER, MICHAEL ANTHONAVAGE, CAREN DRES-HAJESKI, and TOM RUSSO, Vantage Specialty Ingredients, Inc., Global Headquarters, Warren, NJ 07059 ( J.C., P.T., J.R., M.A., C.D., T.R.) and Vantage Performance Materials, Gurnee, IL 60031 (E.L.). Summary Structure/property comparisons were made of chemistries based on renewable 1,3-propanediol (PDO)- versus petroleum-based alkylene oxides as well as comparisons of the respective polyethers, emulsifi ers, and cosmetic formulations based on these feedstocks. Green Chemistry Principles were applied in the manufacture of polyethylene glycol (PEG)-free renewable PDO-based oligomers and PDO-based fatty acid ester emulsifi ers. Sustainable cosmetic products formulated with renewable PDO-based emulsifi ers gave equivalent performance in sensory and moisturization evaluations compared to those formulated with the petroleum-derived PEG- based emulsifi ers. INTRODUCTION Petroleum-based alkylene oxides, i.e., ethylene oxide (EO) (1) and propylene oxide (PO) monomers are widely used feedstocks for the production of polyethylene glycol (PEG) and polypropylene glycol (PPG) polyethers that fi nd application in a variety of industries. PEG and PPG are useful raw materials for the production of alkoxylated fatty acid and alkoxylated fatty alcohol surfactants/emulsifi ers used in the personal care industry. Some of the drawbacks of the ethoxylated nonionic surfactants include that they are petroleum based and contain residual levels of hazardous unreacted EO monomers and 1,4-dioxane by-products (2). For these reasons, there have been efforts to develop PEG-free alternatives. Examples of some of the commercially available PEG-free fatty acid esters include the polyglycerol esters, sorbitol esters, and sucrose esters (3–5). The later surfactants have found success as nonionic PEG-free alternatives in the personal care markets, although the ethoxylate-based chemistry still holds a large share of the nonionic surfactant market in personal care. There remains a need for more sustainable PEG-free nonionic surfactant Address all correspondence to Eric Lind at Eric.Lind@vantagegrp.com.