IOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS TEN VOLUME INDEX Copies of the Index for Volumes I--X (1947-1959) are available at Sw. Fr. 10 per copy from the Swiss Society of Cosmetic Chemists 7, place de la Fusterie Geneva, Switzerland

y. Soc. Cosmetic Chemists, 15• 579-592 (1964) STATISTICAL EVALUATION OF QUANTITATIVE ANTIPERSPIRANT DATA (I) By W. M. Wooding, B.Ch.E., H. E. Jass, Ph.D., and I. Ugelow, M.S.* ABSTRACT An improved method for the quantitative measurement of perspira- tion on human subjects was developed. It consisted of the use of small perforated containers of dehydrated silica gel, designed to be pre- weighed, then taped to subjects' skins so that sweat output could be collected at specific areas. The investigation described in this report was concerned with the evaluation of the ability of these devices to dis- tinguish between typical antiperspirant treatments and other experi- mental variables. In the present case, the antiperspirants were applied in the form of aqueous solutions of active materials. A major object of the study was to test the application of a conventional statis- tical analysis (analysis of variance) to data obtained with the silica gel device. The results indicated that the measurement was sufficiently precise to allow comparisons of the efficacy of some antiperspirant materials with a blank and with each other and that a balanced experimental design plus an analysis of variance was satisfactory, statistically sound and very useful in interpreting the resulting data. INTRODUCTION AND NATURE OF PROBLEM Methods of measurement of human perspiration have generally suffered from a lack of precision and flexibility. Earlier methods depended upon visualization of sweat droplets by color reagents, and quantitation often consisted of a comparative grading of observed results. Thus, starch- iodine mixtures which turned blue at the sweating site were used by Minor (1) and modified variously by many other workers (2-5). Indicators other than starch-iodine, such as bromphenol blue (6) and phenolphthalein (7), have also been utilized by some investigators in a similar manner. The use of electrical conductivity methods (8, 9) have yielded quantira- * Revlon Research Center, Inc., Bronx 10473, N. ¾. 579