SKIN STRIPPING TO DETERMINE METABOLISM 373 should be considered as a potential method to determine whether metabolism can take place rather than providing quantitative information on the extent of cutaneous metab- olism. ACKNOWLEDGMENTS This study was supported in part by Nelson Research and Chantal Pharmaceutical Cor- poration. REFERENCES (1) R. H. Guy, J. Hadgraft, and D. A. W. Bucks, Transdermal drug delivery and cutaneous metabo- lism, Xenobiotica, 17, 325-343 (1987). (2) R. J. Martin, S. P. Denyet, and J. Hadgraft, Skin metabolism of topically applied compounds, Int. J. Pharm., 39, 23-32 (1987). (3) R. B. Stoughton and W. O. McClure, Azone©: A new non-toxic enhancer of cutaneous penetration, Drug Devel. Ind. Pharm., 9, 725-744 (1983). (4) L. C. Ford, H. A. Hammill, R. J. DeLange, D. A. Bruckner, F. Suzuki-Chavez, K. L. Mickus, and T. B. Lebherz, Determination of estrogen and androgen receptors in Trichomonas vaginalis and the effects ofantihormones, Am. J. Obstet. Gynecol., 156, 1119-1121 (1987). (5) J. W. Wiechers, B. F. H. Drenth, J. H. G. Jonkman, and R. A. de Zeeuw, Percutaneous absorp- tion, metabolic profiling and excretion of the penetration enhancer Azone © after multiple dosing of an Azone-containing triamcinolone acetonide cream (TAZ) in humans, J. Pharm. Sci., 79, 111-115 (1990). (6) J. W. Wiechers, R. E. Herder, B. F. H. Drenth, and R. A. de Zeeuw, Percutaneous absorption, disposition, and excretion of x4C-labeled Cyoctol in humans after a single derreal application, Int. J. Pharm. (in press). (7) M. T. Hojyo-Tomoka and A.M. Kligman, Does cellophane tape stripping remove the horny layer? Arch. Dermatol., 106, 767-768 (1972). (8) C. C. Peck, D. P. Conner, B.J. Bolden, R. G. Almirez, T. E. Kingsley, L. D. Mell, M. G. Murphy, V. E. Hill, L. M. Rowland, D. Ezra, T. E. Kwiatkowski, C. R. Bradley, and M. Abdel- Rahim, Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry, Skin Pharmacol., 1, 14-23 (1988). (9) C. C. Peck, D. P. Conner, B.J. Bolden, R. G. Almirez, L. M. Rowland, T. E. Kwiatkowski, B. A. McKelvin, and C. R. Bradley, "Outward Transdermal Migration ofTheophylline," in Pharma- cology and the Skin, B. Shroot and H. Schaefer, Eds. (Karger, Basel, 1987), Vol. 1, pp. 201-208. (10) R. A. de Zeeuw, R. E. Herder, J. W. Wiechers, and B. F. H. Drenth, Metabolic conversion of Cyoctol during skin passage in humans, Pharm. Res. (in press). (11) A. Yacobi, R. A. Baughman, D. B. Cosulich, and G. Nicolau, Method for determination of first- pass metabolism in human skin, J. Pharm. Sci., 73, 1499-1500 (1984). (12) J. W. Wiechers, B. F. H. Drenth, J. H. G. Jonkman, and R. A. de Zeeuw, Percutaneous absorp- tion and elimination of the penetration enhancer Azone in humans, Pharm. Res., 4, 519-523 (1987). (13) J. W. Wiechers, B. F. H. Drenth, J. H. G. Jonkman, and R. A. de Zeeuw, Percutaneous absorp- tion, metabolism, and elimination of the penetration enhancer Azone in humans after prolonged application under occlusion, Int. J. Pharm., 47, 43-49 (1988).

j. Soc. Cosmet. Chem., 40, 375 (November/December 1989) Book Review COSMETIC AND TOILETRY FOR- MULATIONS, 2nd Edition, by Ernest W. Flick. Noyes Publications, Park Ridge, NJ, 1989. Price: $125.00. This 964-page volume of formulations consists of three parts: subject index, for- mulations-making procedures, and raw materials-trade names. It contains more than 1,800 cosmetic formulations based on information obtained from more than 150 different suppliers, whose addresses are listed in the last section of the book. In most cases the formula source is pro- vided, and in many but not all cases, a brief making procedure is described. Each formulation is identified by its end use. The formulations-making procedure sec- tion is divided into 14 different product classes: antiperspirants and deodorants, baby products, bath and shower products, beauty aids, creams, fragrances and per- fumes, hair care products, insect re- pellants, lotions, shampoos, shaving products, soaps, suncare products, and miscellaneous. Each section contains a large number of different types of formu- lations for example, the shampoo section contains more than 100 different types of shampoo formulas. To those beginning in cosmetics and toiletry formulation, this book could be exceedingly useful. Even to those with several years experience, it is a useful ref- erence source, and it offers convenience, since this single volume can be used to re- place large file cabinets of supplier for- mula information. The only drawbacks that this book offers are the steep price and, in some cases, the rather limited information pro- vided on making procedures. Of course, the price is only a drawback to those on a strict budget. The limited making proce- dure information could present problems for the beginning cosmetics formulator, but it is certainly adequate for the experi- enced formulator. Cosmetic and Toiletry Formulations can be a useful and valuable addition to the li- braries of those involved in cosmetics for- mulation.-- CLARENCE R. ROBBINS --Colgate Palmolive Co. 375