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17 Address all correspondence to Zhigang Yin, yinck@zzuli.edu.cn The Design, Preparation, and Performance Testing of Hand Creams to Slow the Spread of Pathogenic Microorganisms XIAOKANG WANG, ZHIGANG YIN, TAIJUN ZHANG, SHUANG GAO, HENGYU QIAN, TONGYAN ZHANG, RUIJUAN WANG AND JING ZHOU School of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan Province, China (X.W., Z.Y., S.G., H.Q., T.Z., R.W., J.Z.) Guangzhou Emperor’s Wisdom Skin Biotechnology Research Institute Co., Ltd, Canton, Guangdong Province, China (T.J.Z.) Acceptance date: December 15, 2021. Synopsis Pathogenic microorganisms spread in every public place, often through human hand contact, thereby endangering health. However, frequent use of disinfecting products to inhibit these microorganisms can cause skin irritation and discomfort. Hand creams that slow the spread of microorganisms are becoming increasingly relevant and necessary for epidemic prevention and control. This article selects a basic formula and adds plant bacteriostatic ingredients to form a hand cream. The minimum inhibitory concentration and bacteriostatic zone tests were used to assess bacteriostatic performance. The mixture of Citrus reticulata peel extract and Lithospermum erythrorhizon extract with a weight ratio of 2:1 exhibited a potent bacteriostatic effect. It was applied to hand cream, compared with commercial products in bacteriostatic tests, and passed the field test. The viscosity, pH, thermal stability, and other physical and chemical properties were tested in addition to a sensory evaluation, skin moisture content test, and transdermal moisture loss test. Using these measures, a hand cream that can effectively slow the spread of microorganisms was obtained. INTRODUCTION People’s daily activities are carried out in environments rich in microorganisms. After coming into contact with human hands, microorganisms can spread extensively even with frequent handwashing. With the normalization of epidemic prevention and control, people’s awareness of the harm caused by pathogenic microorganisms and the need for protection has increased. The use of alcohol-based disinfecting gels and sprays in public places has become more common, effectively reducing the spread of pathogens. However, when used frequently, these materials can cause irritation and even progress to skin problems such as itching, rashes, and allergies. Therefore, a hand cream that effectively prevents the spread of microorganisms while also taking care of your hands is more needed than ever. Three main types of pathogenic microorganisms frequently affect human health: cocci, bacilli, and fungi, for which Staphylococcus aureus, Escherichia coli, and Candida albicans are J. Cosmet. Sci., 73, 17–34 (January/February 2022)