171 Hydrolyzed Conchiolin Protein Inhibits Melanin
endothelin antagonist without unwanted side effects. This suggests that HCP may have
promising applications as a safer skin whitening agent in the future.
REFERENCES
(1) Lambert MW, Maddukuri S, Karanfilian KM, Elias ML, Lambert WC. The physiology of melanin
deposition in health and disease. Clin Dermatol. 2019 37(5):402-417.
(2) Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature. 2007 445:843-850.
(3) Zhou S, Zeng H, Huang J, et al. Epigenetic regulation of melanogenesis. Ageing Res Rev. 2021 69:101349.
(4) Fukuda M. Rab GTPases: key players in melanosome biogenesis, transport, and transfer. Pigment Cell
Melanoma Res. 2021 34(2):222-235.
(5) Hume AN, Seabra MC. Melanosomes on the move: a model to understand organelle dynamics. Biochem
Soc Trans. 2011 39(5):1191-1196.
(6) Fukuda M, Kuroda TS. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c),
a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem.
2002 277(45):43096-43103.
(7) Ménasché G, Pastural E, Feldmann J, et al. Mutations in RAB27A cause Griscelli syndrome associated
with haemophagocytic syndrome. Nat Genet. 2000 25(2):173-176.
(8) Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac
regulates growth factor-induced membrane ruffling. Cell. 1992 70(3):401-410.
Figure 7. A model depicting the molecular mechanism by which HCP inhibits melanosome transfer in
melanocytes through regulating the Wnt signaling pathway.
endothelin antagonist without unwanted side effects. This suggests that HCP may have
promising applications as a safer skin whitening agent in the future.
REFERENCES
(1) Lambert MW, Maddukuri S, Karanfilian KM, Elias ML, Lambert WC. The physiology of melanin
deposition in health and disease. Clin Dermatol. 2019 37(5):402-417.
(2) Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature. 2007 445:843-850.
(3) Zhou S, Zeng H, Huang J, et al. Epigenetic regulation of melanogenesis. Ageing Res Rev. 2021 69:101349.
(4) Fukuda M. Rab GTPases: key players in melanosome biogenesis, transport, and transfer. Pigment Cell
Melanoma Res. 2021 34(2):222-235.
(5) Hume AN, Seabra MC. Melanosomes on the move: a model to understand organelle dynamics. Biochem
Soc Trans. 2011 39(5):1191-1196.
(6) Fukuda M, Kuroda TS. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c),
a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem.
2002 277(45):43096-43103.
(7) Ménasché G, Pastural E, Feldmann J, et al. Mutations in RAB27A cause Griscelli syndrome associated
with haemophagocytic syndrome. Nat Genet. 2000 25(2):173-176.
(8) Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac
regulates growth factor-induced membrane ruffling. Cell. 1992 70(3):401-410.
Figure 7. A model depicting the molecular mechanism by which HCP inhibits melanosome transfer in
melanocytes through regulating the Wnt signaling pathway.








































































