187 POLYPODIUM LEUCOTOMOS EXTRACT
(26) Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell. 1995 80(1):83–93.
(27) Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the
genome. DNA Repair. 2004 3(8–9):959–967.
(28) Molinuevo R, Freije A, Contreras L, Sanz JR, Gandarillas A. The DNA damage response links human
squamous proliferation with differentiation. J Cell Biol. 2020 219(11):e202001063.
(29) Candi E, Schmidt R, Melino G. The cornified envelope: A model of cell death in the skin. Nat Rev Mol
Cell Biol. 2005 6(4):328–340.
(30) Wong CW, LeGrand CF, Kinnear BF, et al. In vitro expansion of keratinocytes on human dermal
fibroblast-derived matrix retains their stem-like characteristics. Sci Rep. 2019 9(1):18561.
(31) Paladini RD, Takahashi K, Bravo NS, Coulombe PA. Onset of re-epithelialization after skin injury
correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential
role for keratin 16. J Cell Biol. 1996 132(3):381–397.
(32) Cuddihy AR, O’Connell MJ. Cell-cycle responses to DNA damage in G2. Int Rev Cytol. 2003 222:
99–140.
(33) Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-
strand breaks in vivo. J Cell Biol. 1999 146(5):905–916.
(34) Zhang Y, Li Z, Hao Q, et al. The CDK2–c-myc–miR-571 axis regulates DNA replication and genomic
stability by targeting geminin. Cancer Res. 2019 79(19):4896–4910.
(35) Watt FM, Broad S, Prowse DM. et al. Cultivation and retroviral infection of human epidermal
keratinocytes. In: JE Celis, ed. Cell Biology: A Laboratory Handbook Elsevier Science. Elsevier. 3rd ed
2006:133–138.
(36) Kusano C, Takao S, Noma H, et al. N-acetyl cysteine inhibits cell cycle progression in pancreatic
carcinoma cells. Hum Cell. 2000 13(4):213–220.
(37) Thangapazham RL, Singh AK, Sharma A, Warren J, Gaddipati JP, Maheshwari RK. Green tea
polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer
cells in vitro and in vivo. Cancer Lett. 2007 245(1-2):232–241.
(38) Garcia F, Pivel JP, Guerrero A, et al. Phenolic components and antioxidant activity of Fernblock, an
aqueous extract of the aerial parts of the fern Polypodium leucotomos. Methods Find Exp Clin Pharmacol.
2006 28(3):157–160.
(39) Rheinwald JG, Green H. Formation of a keratinizing epithelium in culture by a cloned cell line derived
from a teratoma. Cell. 1975 6(3):317–330.
(40) Sanz-Gómez N, Freije A, Gandarillas A. Keratinocyte differentiation by flow cytometry. Methods Mol
Biol. 2020 2109: 83–92.
(26) Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell. 1995 80(1):83–93.
(27) Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the
genome. DNA Repair. 2004 3(8–9):959–967.
(28) Molinuevo R, Freije A, Contreras L, Sanz JR, Gandarillas A. The DNA damage response links human
squamous proliferation with differentiation. J Cell Biol. 2020 219(11):e202001063.
(29) Candi E, Schmidt R, Melino G. The cornified envelope: A model of cell death in the skin. Nat Rev Mol
Cell Biol. 2005 6(4):328–340.
(30) Wong CW, LeGrand CF, Kinnear BF, et al. In vitro expansion of keratinocytes on human dermal
fibroblast-derived matrix retains their stem-like characteristics. Sci Rep. 2019 9(1):18561.
(31) Paladini RD, Takahashi K, Bravo NS, Coulombe PA. Onset of re-epithelialization after skin injury
correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential
role for keratin 16. J Cell Biol. 1996 132(3):381–397.
(32) Cuddihy AR, O’Connell MJ. Cell-cycle responses to DNA damage in G2. Int Rev Cytol. 2003 222:
99–140.
(33) Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-
strand breaks in vivo. J Cell Biol. 1999 146(5):905–916.
(34) Zhang Y, Li Z, Hao Q, et al. The CDK2–c-myc–miR-571 axis regulates DNA replication and genomic
stability by targeting geminin. Cancer Res. 2019 79(19):4896–4910.
(35) Watt FM, Broad S, Prowse DM. et al. Cultivation and retroviral infection of human epidermal
keratinocytes. In: JE Celis, ed. Cell Biology: A Laboratory Handbook Elsevier Science. Elsevier. 3rd ed
2006:133–138.
(36) Kusano C, Takao S, Noma H, et al. N-acetyl cysteine inhibits cell cycle progression in pancreatic
carcinoma cells. Hum Cell. 2000 13(4):213–220.
(37) Thangapazham RL, Singh AK, Sharma A, Warren J, Gaddipati JP, Maheshwari RK. Green tea
polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer
cells in vitro and in vivo. Cancer Lett. 2007 245(1-2):232–241.
(38) Garcia F, Pivel JP, Guerrero A, et al. Phenolic components and antioxidant activity of Fernblock, an
aqueous extract of the aerial parts of the fern Polypodium leucotomos. Methods Find Exp Clin Pharmacol.
2006 28(3):157–160.
(39) Rheinwald JG, Green H. Formation of a keratinizing epithelium in culture by a cloned cell line derived
from a teratoma. Cell. 1975 6(3):317–330.
(40) Sanz-Gómez N, Freije A, Gandarillas A. Keratinocyte differentiation by flow cytometry. Methods Mol
Biol. 2020 2109: 83–92.
