436 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Copper toxicity, environmental hair, reen discoloration, 1 pper sulfate toxicity, environmental hair, green discoloration, 1 Cosmetics allergies prevention, use of anti- irritants, 415 bergapten chromatography, 393 emulsions structure, 3 phase, 309 hair preparations, see also Hair preparations hair preparations comparison, effects of some reactive chemicals on proteins, 401 moisture transepidermal, loss, measurement, equipment, 181 odors evaluations, perceived flagrance complexity, humans, 253 methodology, psychophysical measurements, 91 parebens preservatives, selection, emulsions, 25 preservatives evaluations, linear regression method, 321 raw materials analysis, nitrite and nitrosamines, 127 surface active agents effects, keratin structure, 41 Creams moisture transepidermal, loss prevention, evaluation, equipment, 181 preservatives evaluations, linear regression method, 321 sodium nitrite colorimetry, 385 Deeerie effects skin, biosynthesis, rabbits, 263 Degradation, see Stability Detergents absorption keratin, structure effects, 41 alcohols sulfates, ether sulfates and ethoxylates, rat skin, 157 m-Diamines reactions p-aminophenols, oxidation, hair dyes, 191 Dimethyl sulfide odors oral, GLC evaluations, oral bacteria, 241 2,2'-Dithiobispyridine chromatography, liquid shampoos, 73 2,2'-Dithiobis-pyridine- 1,1 '-dioxide chromatography, liquid shampoos, 73 Dosage schedules t•trahydrozoline toxicity, eye irritanOn, humans, 67 Drug administration antiperspirants aluminum, salts, effects, absorption, 357 Drug analysis, see Analysis Drug stability, see Stability Drugs absorption, see Absorption administration, see Drug administration binding, see Binding nonprescription, see Drugs, over-the- counter over-the-counter, see Drugs, over-the- counter Drugs, adverse reactions see also Toxicity cosmetics allergies, reduction using anti-irritants, 415 Drugs, clinical effectiveness antiperspirants aluminum, salts, 357 Drugs, over-the-counter tetrahydrozoline toxicity, eye irritation studies, humans, 67 Dyes hair oxidetire, p-aminophenol reactions, 191 Emollients effects occlusion, skin, measurement, using transepidermal water loss, humans, 345 Emulsions hydrophilic ointment structure, gels, DAB 7, 9 methodology occlusion, skin, measured using transepidermal water loss, humans, 345 oil-in-water Formulations, surfactant concentration, 167 parebens preservatives, selection, 25 structure 3 phase, 309 Environmental toxicity, see Toxicity, environmental Equipment moisture transepidermal, loss, use in occlusive screening evaluation, 181 Eye drops, see Solutions, ophthalmic Films nylon 6 use, equipment, determining transepidermal loss, 181 Foams stability effects, transient antifoams, 105 Formulations antiperspirants sticks, silicones, 137 cosmetics anti-irritants, allergy prevention, 415 emulsions oil-in-water, low concentration of surfactant, 167 Gels shampoos formulations, nonirritant, 415 structure hydrophilic ointment, DAB 7,9 Glycerin nitrites: analysis, cosmetics, 127 Hair discoloration green, due to water copper content, 1 dyes reactions, oxidation, p- aminophenol reactions, 191 Hair preparations chemicals comparison, effects on proteins of whole hair, cuticle and cortex, 401 Hardness antiperspirants sticks,

SUBJECT INDEX 437 effects, stearyl alcohol-volatile silicones formulations, 137 Heat, see Temperature Humidity, see Moisture Hydrogen sulfide odors oral, GLC evaluations, oral bacteria, 241 Hydrophilic ointment structure German Pharmacopeia, DAB 7, 9 Hydroxyindophenols dyes hair, oxidative p-aminophenol reactions, 191 N-(p-Hydroxyphenyl) aminobenzoquinone aliimines dyes hair, oxidative p-aminophenol reaction, 191 Hypersensitivity, see Allergies Isoeugenol odors evaluations, perceived fragrance complexity, humans, 253 Isopropyl myristate effects skin, biosynthesis, rabbits, 263 Keratin structure effects, surfactants, 41 Lanolin allergies prevention, using anti-irritants, 415 Linalyl acetate odors evaluations, perceived fragrance complexity, humans, 253 Lotions moisture transepidermal, loss prevention, evaluation, equipment, 181 preservatives evaluations, linear regressran method, 321 sodium nitrite colorimetry, 385 Mechanism of action aluminum chloride: anhidrosis, humans, 279 anti-irritants chemicals, cosmetics, 415 Metabolism absorption, see Absorption binding, see Binding Methodology absorption percutaneous, guinea pig, comparison, fetal hog skin, 375 percutaneous, monkey model, 297 moisture loss, skin, occlusivity of oils, humans, 345 loss, transepidermal, measurement, 369 transepidermal, loss from dry and normal skin, measurement, humans, 333 transepidermal, loss, occlusive screening evaluation, equipment, 181 odors oral, instrumental evaluation using specific oral bacteria, 241 perfumes, psychophysical measurements, 91 preservatives evaluations, linear regression method, 321 stratum corncure topology, relief structure, 213 sunscreen agents evaluations, protection factor, humans, 81 tetrahydrozoline toxicity, accelerated one day eye irritation study, humans, 67 toxicity oils, cosmetics, effects, skin biosynthesis, rabbits, 263 Methyl mercaptan odors oral, GLC evaluations, oral bacteria, 241 Mineral oil occlusion skin, measurement, using transepidermal water loss, humans, 345 Models absorption percutaneous, monkey, 297 skin guinea pig, comparison, fetal hog, percutaneous absorption, 375 Moisture skin loss, transepidermal, measurement, 369 occlusivity, methodology, transepidermal water loss, humans, 345 transepidermal loss, evaluation, equipment, occlusive screening, 181 loss, from normal and dry skin, measurement, humans, 333 Musk odors evaluations, perceived fragrance complexity, humans, 253 a-Naphthol absorption skin, guinea pig, fetal hog, 375 Nitrites cosmetics analysis, 127 Nitrosamines cosmetics analysis, 127 N-Nitrosodiethanolamine chromatography, liquid cosmetics, alkanolamides, 127 Nylon 6 films use, equipment, determining transepidermal moisture loss, 181 Odors evaluations perceived fragrance complexity, humans, 253 oral methodology, instrumental evaluation using oral bacteria, 241 perfumes evaluations, psychophysical, 91 Oils bergamot, see Bergamot oil cosmetics toxicity, skin biosynthesis effects, rabbits, 263 films skin, occlusivity, methodology, transepidermal water loss, humans, 345 Omadine MDS, see 2,2'-Dithiobis- pyridine- 1,1 '-dioxide Ophthalmic preparations solutions, see Solutions, ophthalmic O-T-C drugs, see Drugs, over-the- counter Parabens preservatives emulsions, selection, 25 Paraffin occlusion skin, measurement, using transepidermal water loss, humans, 345