INFLUENCE OF DEPLETION ON PERCUTANEOUS ABSORPTION 245 0.8 0.6 0.4 I I I I I I I I I I .0001 .001 .01 .1 1 10 VOLUME (ml) Figure 7. Effect of value of K on maximum penetration rate for various donor volumes. K•/K_• = 10. z ^ B c O I I I I I I I I I I 4 B 12 16 20 TIME (HR) Figure 8. Amount on the surface (fraction of applied dose) as a function of time. Donor volume 0.0032 ml. Key: (A) K = 0.2 hr-t (B) K = 0.4 hr-t (C) K = 0.6 hr -•' (D) K = 0.8 hr -•
246 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS ILl Z ,•- ILl •.- Z Z A B • I I I I I I I I I I O 4 8 12 16 20 TIME (HR) Figure 9. Amount in the membrane (fraction of applied dose) as a function of time. Details as for Figure 8. 0 4 8 12 16 20 TIME (HR) Figure 10. Amount penetrated (fraction of applied dose) as a function of time. Details as for Figure 8.
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