Table I Effects of MEL/NB-UVB Alone (A), MEL/NB-UVB +MT (B), and MEL/NB-UVB +MTK (C) on Epidermal Melanocytes/Melanoblasts and Dermal Collagen and Elastin Fibers in the Vitiliginous Skin No Gender (Age) Skin Site MEL/NB-UVB (No. of sess) Dose (j/cm2) MT/MTK (Days) M Non M Les M Tre Mb Non Mb Les Mb Tre Coll Non Coll Les Coll Tre Elas Non Elas Les Elas Tre (A) MEL/NB-UVB alone 1 F (12) Elbow MEL(13) +NB(12) 20.7 0 79.8 0 0 94.2 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 2 F (47) Back MEL(3) 0.4 0 79.0 0 0 91.4 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 3 F (12) Leg MEL(8) 2.1 0 129.1 0 0 91.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓↓ 4 M (6) Eyelid MEL(42) +NB(1) 21.2 0 107.8 0 0 99.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 5 M (21) Cheek MEL (40) +NB (1) 15.4 0 132.7 0 0 103.3 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓ ↓ 6 M (70) Neck MEL(35) +NB(42) 86.0 0 53.7 0 0 95.0 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 7 F (53) Finger MEL(20) +NB(3) 67.3 0 112.2 0 0 98.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 8 M (50) Hip MEL(5) 2.0 0 84.9 0 0 98.4 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 9 M (74) Face MEL(3) +NB(8) 4.6 0 73.8 0 0 117.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 10 F (29) Nipple MEL(15) +NB(7) 7.0 0 85.8 0 0 114.7 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 11 M (30) Chin MEL(10) +NB(10) 8.9 0 140.2 0 0 97.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓↓ 12 M (26) Eyelid MEL(36) +NB(47) 89.1 0 150.2 0 0 119.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 13 M (29) Neck MEL(16) +NB(1) 6.7 0 138.1 0 0 113.2 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑ ↓ ↓ 14 M (33) Neck MEL(4) +NB(76) 126.9 0 85.4 0 2.4 127.5 0 5.1 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 15 M (72) Arm MEL(3) 1.6 0 52.9 0 0 107.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 16 M (45) Wrist MEL(3) +NB(17) 15.5 0 155.3 0 0 102.4 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓↓ 17 F (37) Areola MEL(11) +NB(10) 5.9 0 78.6 0 0 104.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ (B) MEL/NB-UVB +MT 18 F (61) Neck MEL(14) +NB(13) 40.8 91 130.7 0 0 109.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 19 M (79) Scalp MEL(20) +NB(16) 25.8 89 102.6 0 0 96.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 20 M (50) Wrist NB(38) 34.2 92 118.3 0 0 112.0 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 21 M (15) Neck MEL(1) +NB(2) 0.9 7 111.3 0 0 98.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 22 F (44) Neck MEL(18) +NB(10) 10.4 109 197.7 0 11.0 104.3 0 2.4 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 23 M (56) Hand MEL(1) +NB(12) 8.1 51 165.2 0 0 108.5 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 24 F (35) Belly MEL(11) +NB(9) 7.4 118 99.7 0 0 94.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 25 F (49) Neck MEL(18) +NB(16) 19.8 102 97.0 0 0 91.9 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑ 26 M (73) Neck NB(14) 6.5 67 103.2 0 0 105.7 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 27 F (14) Eyelid MEL(3) 0.2 11 130.5 0 1.9 102.7 0 22.8 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ ()393 MESENCHYMAL STEM CELL-DERIVED FACTORS

Table I ()Effects of MEL/NB-UVB Alone (A), MEL/NB-UVB +MT (B), and MEL/NB-UVB +MTK (C) on Epidermal Melanocytes/Melanoblasts and Dermal Collagen and Elastin Fibers in the Vitiliginous Skin No Gender (Age) Skin Site MEL/NB-UVB (No. of sess) Dose (j/cm2) MT/MTK (Days) M Non M Les M Tre Mb Non Mb Les Mb Tre Coll Non Coll Les Coll Tre Elas Non Elas Les Elas Tre 28 M (71) Chin MEL(2) 0.8 12 79.6 0 16.9 106.6 0 38.4 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑ ↓↓ ↑↑ 29 M (13) Chin NB(2) 0.6 5 79.2 0 0 104.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↓↓↓ 30 F (23) Hip NB(1) 1.0 6 103.0 0 0 94.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑ 31 F (8) Face MEL(3) 0.7 10 85.0 0 0 97.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 32 M (17) Chin MEL(4) 0.4 14 78.4 0 0 108.1 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 33 M (23) Nose MEL (4) 1.0 6 153.3 0 0 97.5 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓↓ 34 F (20) Areola MEL(7) +NB(3) 1.7 31 72.1 0 0 80.2 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓↓ (C) MEL/NB-UVB +MTK 35 F (76) Face NB(6) 3.0 14 150.5 0 0 107.3 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 36 F (28) Chin MEL(4) 0.7 14 70.8 0 0 94.2 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 37 M (36) Neck MEL(3) 0.2 18 77.5 0 0 98.5 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 38 F (45) Face MEL(4) +NB(1) 0.8 8 87.5 0 0 90.0 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 39 M (10) Head MEL(5) 1.0 23 157.4 0 0 123.8 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 40 F (21) Head MEL(3) 0.4 17 86.3 0 0 113.2 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 41 F (11) Shoulder MEL(7) +NB(7) 3.6 104 127.5 0 16.3 103.8 0 17.8 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 42 M (4) Head MEL(27) 9.5 75 98.3 0 58.4 95.8 0 61.9 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 43 M (33) Neck NB(7) 4.6 25 134.8 0 29.5 117.4 0 19.0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 44 M (15) Head MEL(1) +NB(21) 17.9 168 110.9 0 105.7 104.3 0 98.9 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 45 M (65) Face MEL(7) +NB(6) 5.1 24 120.8 0 0 106.5 0 0 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 46 F (72) Neck MEL (2) +NB(1) 2.5 13 144.7 0 41.3 128.4 0 35.7 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 47 F (27) Face NB(6) 3.5 21 124.9 0 8.7 101.5 0 45.2 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 48 M (21) Chin MEL(3) +NB(2) 1.2 14 84.9 0 51.1 114.2 0 67.5 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ 49 M (37) Neck MEL (3) 0.3 21 105.3 0 18.8 114.2 0 20.4 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 50 F (56) Hand MEL(25) +NB(1) 204.9 44 87.0 0 3.7 119.7 0 3.7 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓↓ ↑↑↑ 51 F (71) Arm NB(20) 21.0 76 98.5 0 107.6 103.5 0 97.5 ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↑↑↑ Sessions (sess) of MEL (308 nm) and/or NB-UVB (NB, 311 nm) were performed on the skin of 51 vitiligo patients. MT, MEL/NB-UVB +FFC +collagen peptide +elastin peptide MTK, MT +UCB-MSCCS F, female M, male M, melanocyte population/0.1 mm2 Mb, melanoblast population/0.1 mm2 Non, nonlesional Les, lesional Tre, treatment with MEL/NB-UVB and/or MT/MTK Coll, collagen fiber Elas, elastin fiber ↓slightly decreased ↓↓decreased ,↓↓↓decreased ,dramatically ↑slight recovery ↑↑moderate ,recovery or slightly reduced density compared with nonlesional skin ↑↑↑full ,recovery. 394 JOURNAL OF COSMETIC SCIENCE