TOPICAL APPLICATION OF SOY MILK EXTRACT 479 (11) K. Miyazaki, T. Hanamizu, R. Iizuka, and K. Chiba, Genistein and daidzein stimulate hyaluronic acid production in transformed human keratinocyte culture and hairless mouse skin, Skin Pharmaco/. App/. Skin Physio/., 15, 175-183 (2002). (12) H. Kikuchi-Hayakawa, N. Onodera, S. Matsubara, E. Yasuda, Y. Shimakawa, and F. Ishikawa, Effects of soya milk and bifidobacterium-fermented soya milk on plasma and liver lipids, and faecal steroids in hamsters fed on a cholesterol-free or cholesterol-enriched diet, Br. J. N/•tr., 79, 97-105 (1998). (13) T. Ohta, S. Nakatsugi, K. Watanabe, T. Kawamori, F. Ishikawa, M. Morotomi, S. Sugie, T. Toda, T. Sugimura, and K. Wakabayashi, Inhibitory effects of Bifidobacteri•m-fermented soy milk on 2-amino- 1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis with a partial con- tribution of its component isoflavones, Carcinogenesis, 21, 937-941 (2000). (14) M. Kano, F. Ishikawa, S. Matsubara, H. Kikuchi-Hayakawa, and Y. Shimakawa, Soymilk products affect ethanol absorption and metabolism in rats during acute and chronic ethanol intake, J. Natr., 132, 238-244 (2002). (15) K. Miyazaki, T. Hanamizu, R. Iizuka, and K. Chiba, Bifidobacteriam-fermented soy milk extract stimulates hyaluronic acid production in human skin cells and hairless mouse skin, Skin Pharmacol. Appl. Skin Physiol., 16, 108-] 16, (2003). (16) H. Tagami, M. Ohi, K. Iwatsuki, Y. Kanamaru, M. Yamada, and B. Ichijo, Evaluation of the skin surface hydration in vivo by electrical measurement,J. Invest. Dermatol., 75, 500-507 (1980). (17) M. Uzuka, K. Nakajima, S. Ohta, and Y. Mori, The mechanism of estrogen-induced increase in hyaluronic acid biosynthesis, with special reference to estrogen receptor in the mouse skin, Biochim. Biophys. Acta, 627, 199-206 (1980). (18) V. Breinholt and C. Larsen, Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay, Chem. Res. Toxicol., 11, 622-629 (1998). (19) M.J. Thornton, The biological actions of estrogens on skin, Exp. Dermatol., 11,487-502, (2002).

j. Cosmet. sci., 55,481-483 (September/October) 2004 Abstracts International Journal of Cosmetic Science Vol. 26, No. 3, 2004* Physicochemical Factors Affecting The Rapid Bactericidal Efficacy Of The Phenolic Antibacticeral Triclosan' Timothy J. Taylor, E. Phil Seitz, Priscilla Fox, George E. Fischlcr, Janice L. Fuls, and Patrick L. Weidner Dial Center for Innovation, 15101 North Scottsdale Road, Scottsdale, Arizona 85254 The antimicrobial activity of triclosan (TCS 2,4,4'- trichloro-2'-hydroxydiphenyl ether) in aqueous solutions is shown to directly depend upon two key physicochemical parameters: percent saturation and saturation solubility. Saturated solutions of TCS in water, in water-propylene glycol mixtures, and in aqueous surfactant systems are shown to effect rapid, potent bacterial reductions (e.g., 41og•o reduction of Staphylococcus aureus in 15 s contact time in a time kill suspension test). In surfactant solutions, increasing the suffactant:TCS ratio causes a decrease in antibacterial efficacy, consistent with a model for miceliar solubilization where the micelle binding constant, g(: X), increases with decreasing TCS C w concentration in the micelles (X), resulting in decreased concentration of bioavailable TCS in the water (continuous) phase (c,•). The rapid and potent reductions of bacteria reported here were surprising and support the existence of a non-specific mode of action for TCS, such as gross membrane disruption, in addition to the specific modes of action reported by others. Original Semiological Standardized Standardized Evaluation of Stratum Corneum Hydratrion By Diagnoskin© Stripping Sample P. Gasser*, L. Peno-Mazzarino*, E. Lati*, and B. Djian# *Centre de Recherches Biologiques et d'Expdrimentation Cutandes, Laboratoire BIO-EC, Clamart France #Dermatologist 54, avenue Kleber 75116 Paris, France In a normal and healthy skin, the regular elimination of the superficial comeocytes, called desquamation, is a fundamental physiological process intended to protect the barrier function of the skin. This invisible loss of corneocytes, individually or by small groups, is incessantly compensated by the divisions of the proliferative layer and the upward cellular maturation in order to maintain the harmonious renewal of the epidermis and the integrity of the stratum corneunz The harmony of this desquamation process is intimately conditioned by a sufficient hydration of the stratum corneum: (i) An abnormal desquamation leads to a disruption of the water barrier function and consequently to a dehydration tendency of the stratum corncure, and (ii) a cutaneous dryness (whatever the cause) is able to disturb the desquamation process. Protecting the water content of the stratum corneum has always been a major preoccupation of the cosmetic industry scientists. Consequently, the moisturizing properties of a cosmetic product are objectively measured by various explorations directly targeted on the hydration (corneometry) and on the * These abstracts appear as they were originally published. They have not been edited by the Journal of Cosmetic Science. 481