424 JOURNAL OF COSMETIC SCIENCE In GA peel group, average baseline score was 14.37 after 6 week score was reduced to 12.12 and at the end of treatment (14 weeks), it was further reduced to an average score of 6.32. There was a significant difference between baseline and at the end of treatment MASI score. (Tables V, VI) Statistical analysis: Paired t-test was applied. 1. For baseline and 6 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 2. For baseline and 14 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 (Statistical significance at the level of 95% confidence interval) Average reduction in MASI score in cases with GA peel group = 58.56% (Figures 1, 2, 3, 4) In JP group, the average baseline score was 15.68, after 6 week score was reduced to 8.5, and at the end of treatment (14 week), it was further reduced to average score of 6.28. (Figures 5, 6, 7, 8). There was a significant difference between baseline and at the end of treatment MASI score. (Table VII) Statistical analysis: Paired t-test was applied. • For baseline and 6 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 • For baseline and 14 weeks MASI score: Extremely statistically significant difference was found between the two groups p 0.0001 (Statistical significance at the level of 95% confidence interval) Average reduction in MASI score in cases with JP group = 59.12% In GA peel group, 84% cases had moderate to good improvement, whereas in JP group 92% cases had moderate to good improvement. (Table VIII) Table IX Pre- and Posttreatment Average MASI Score: at the 0 Week (i.e. Baseline) and at the 14 Week (i.e. End of Treatment) Peel Group Average MASI score Percentage Improvement (%) Pretreatment Posttreatment Glycolic acid peel (n = 25) 14.37 6.32 58.56 Jessner peel (n = 25) 15.68 6.28 59.12 MASI: Melasma Area and Severity Index. Table X Adverse Cutaneous Side Effects (n = 50) Type of side effects Glycolic acid peel (n = 25) Jessner peel (n = 25) Total Erythema 6 14 20 Burning 4 6 10 Pigmentation 3 2 5 Dry skin 1 2 3
425 COMPARATIVE EFFICACY OF 35% GLYCOLIC ACID PEEL Figure 1. Pretreatment glycolic acid peel. Figure 2. Posttreatment glycolic acid peel.
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