EFFICACY OF TRICLOSAN 229 Table V Effect of Antiperspirant Deodorant Roll-Ons on Axillae Bacterial Populations Day Mean log•o bacteria/cm 2 skin + SD Hour Aluminum chlorhydrate Plus 0.2% triclosan Significance of difference (8 h) 1 2.96 -+ 0.49 2.85 -+ 0.45 4 3.42 -+ 0.70 3.04 -+ 0.54 6 3.49 -+ 0.56 3.52 -+ 0.63 8 3.68 -+ 0.57 3.64 -+ 0.48 1 2.60 -+ 0.50 2.44 -+ 0.48 4 3.68 -+ 0.61 2.94 -+ 0.63 6 3.52 -+ 0.59 3.10 -+ 0.72 8 4.00 _+ 0.52 3.50 -+ 0.54 1 2.89 -+ 0.59 2.57 -+ 0.62 4 3.31 -+ 0.61 3.34 -+ 0.69 6 3.66 -+ 0.52 3.34 -+ 0.64 8 4.06 _+ 0.55 3.58 -+ 0.51 3.07 -+ 0.70 2.65 -+ 0.65 3.55 -+ 0.70 2.93 -+ 0.73 3.76 + 0.56 3.45 -+ 0.56 4.31 -+ 0.58 3.71 -+ 0.71 1 2.95 + 0.61 2.45 + 0.59 4 3.51 - 0.77 2.92 _ 0.80 6 3.87 - 0.53 3.23 - 0.49 8 4.26 _ 0.69 3.65 - 0.59 2or. 0.05 2or. 0.01 2c• 0.01 2or 0.01 2or 0.01 in the axillae 4 h after application to, on average, 2.57 X 103/cm 2 skin and 4.90 X 103/cm 2 skin, respectively. Antibacterial efficacy of both the roll-on and stick was sig- nificantly enhanced by inclusion of triclosan, particularly following repeated applica- tion. In the case of the stick composition, an antibacterial action due to the active antiperspirant ingredient was supported in a parallel study where the base formulation (no aluminum-zirconium tetrachlorohydrex-glycine complex or triclosan included) had Table VI Effect of Antiperspirant Deodorant Sticks on Axillae Bacterial Populations Mean log•o bacteria/cm 2 skin _+ SD Day Hour Base formulation Plus ZAG z Plus ZAG & 0.3% triclosan Significance of difference ZAG • ZAG + triclosan 1 4 5.49 _ 0.52 3.83 - 0.59 24 4.42 _ 0.60 4 4 5.36 -+ 0.32 3.49 -+ 0.49 24 -- 3.97 -+ 0.55 3.18 - 0.67 4.02 - 0.84 2.75 m 0.70 3.05 -+ 0.72 2or 0.01 2or 0.01 2or 0.01 2or 0.01 • Aluminum-zirconium tetrachlorohydrex-glycine complex.

230 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS ß ontiperspiront roll--on ß plus 0.2•. tricloson O I I I I I 1 h 2h 4h 6h 8h Hours affer applicafion Figure 2. Sustained antibacterial effect of antiperspirant deodorant roll-ons. Mean recoveries of axillae bacteria over 8 h. ß ontiperspiront stick ß plus o.• triclosan ß base formulation Number of applicafions Figure 3. Reduction in axillae bacteria 4 h after application of antiperspirant deodorant sticks.